双相赖脯胰岛素50和双相赖脯胰岛素25对新发2型糖尿病的疗效及安全性比较  

Effectiveness and safety of diphasic insulin lispro 50 versus diphasic insulin lispro 25 in patients with new-onset type 2 diabetes mellitus

作　　者：李冲[1] 王亭亭[1] 翟绍忠[1] 郑丽丽[1] Li Chong;Wang Tingting;Zhai Shaozhong;Zheng Lili(Department of Endocrinology and Metabolism,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院内分泌及代谢科,450052

出　　处：《中国实用医刊》2020年第10期79-82,共4页Chinese Journal of Practical Medicine

摘　　要：目的:比较双相赖脯胰岛素50和双相赖脯胰岛素25对新发2型糖尿病的疗效及安全性。方法:抽取2017年8月至2019年8月于郑州大学第一附属医院就诊的新发2型糖尿病患者192例为研究对象,应用随机数字表将其分为两组,每组96例,LM25组给予双相赖脯胰岛素25皮下注射2~3次/d,LM50组给予双相赖脯胰岛素50皮下注射2~3次/d。治疗12周,比较两组患者血糖及血糖达标者特征。结果:治疗12周,LM50组最大血糖波动幅度(LAGE)为(5.3±3.2)mmol/L、餐后血糖波动幅度(PPGE)为(4.8±3.9)mmol/L,低于LM25组的(7.8±4.4)mmol/L、(6.0±9.0)mmol/L,P<0.05。LM25组血糖达标者年龄、病程小于未达标者(P<0.05),胰岛素注射3次占比大于未达标者(P<0.05),低血糖发生率、胰岛素总用量高于未达标者(P<0.05)。LM50组血糖达标者年龄、胰岛素注射3次占比大于未达标者(P<0.05)。两组均未出现严重低血糖事件,LM50组夜间低血糖事件发生率为7.3%(14/192),低于LM25组[10.9%(21/192)]。结论:双相赖脯胰岛素50和双相赖脯胰岛素25控制血糖均安全有效,双相赖脯胰岛素50在控制餐后血糖和减少血糖波动上具有优势。双相赖脯胰岛素25可能导致夜间低血糖,需加强夜间血糖监测。Objective To compare the effectiveness and safety of diphasic insulin lispro 50 versus diphasic insulin lispro 25 in patients with new-onset type 2 diabetes.Methods A total of 192 patients with new-onset type 2 diabetes in the First Affiliated Hospital of Zhengzhou University from August 2017 to August 2019 were selected as objects of the study.The enrolled patients were divided into two groups by random number table method,with 96 cases in each group.The LM25 group received insulin lispro mix 25 twice or three times a day,and the LM50 group received insulin lispro mix 50 in the same way.After 12 weeks of treatment,the characteristics of blood glucose and those who reached the standard were compared between the two groups.Results After 12 weeks of treatment,the maximum blood glucose fluctuation range(LAGE)in the LM50 group was(5.3±3.2)mmol/L,and the postprandial blood glucose fluctuation(PPGE)was(4.8±3.9)mmol/L,which was lower than the(7.8±4.4)mmol/L,(6.0±9.0)mmol/L in the LM25 group,P<0.05.The age of the person with the LM25 group of blood glucose standards,the course of disease were less than those of sub-standard(P<0.05),the proportion of 3 insulin injections of insulin injections was higher than that of sub-standard(P<0.05),the incidence of hypoglycemia,proportion of 3 insulin injections were higher than those of sub-standard(P<0.05).There were no serious hypoglycemia events in either group,and the nocturnal hypoglycemia event rate of 7.3%(14/192)in the LM50 group was lower than 10.9%(21/192)in the LM25 group.Conclusions Both diphasic insulin lispro 25 and diphasic insulin lispro 50 were effective and safe in improving glycemic control in patients with on-newset type 2 diabetes.In addation,LM50 had more advantages in controlling postpranpranical blood glucose and decreasing glucose excursion.Diphasic insulin lispro 25 may cause hypoglycemia at night,so we need to strengthen blood glucose monitoring at night.

关 键 词：2型糖尿病 血糖 双相赖脯胰岛素 

分 类 号：R587.1[医药卫生—内分泌]