Ming-Phos/Gold(Ⅰ)-Catalyzed Stereodivergent Synthesis of Highly Substituted Furo[3,4-d][i,2]oxazines  

作　　者：Lujia Zhou Bing Xu Danting Ji Zhan-Ming Zhang Junliang Zhang 

机构地区：[1]Shanghai Key Laboratory of Green Chemistry and Chemical Processes,School of Chemistry and Molecular Engineering East China Normal University,Shanghai 200062,China [2]Department of Chemistry,Fudan University,2005 Songhu Road,Shanghai 200438,China

出　　处：《Chinese Journal of Chemistry》2020年第6期577-582,共6页中国化学（英文版）

基　　金：the fundi ng support of NSFC(Nos.21425205,21672067,21801078);973 Program(No.2015CB856600);the Program of Eastern Scholar at Shanghai Institutions of Higher Learning and the China Postdoctoral Science Foundation(Nos.2019M650071,2019M661418).

摘　　要：A gold(Ⅰ)-catalyzed asymmetric intermolecular tandem[3+3]-cyclization reaction of 2-(l-alkynyl)-2-alken-l-ones with nitrones has been developed by using Ming-Phos as a chiral ligand.This method enables access to the stereodivergent synthesis of highly substituted furo[3,4-d][l,2]oxazines in excellent efficiency and stereoselectivity(up to 99% yield,99% ee,>20:1 dr).

关 键 词：SUBSTITUTED HIGHLY 

分 类 号：O62[理学—有机化学]