COVID-19疫苗的研究进展  

Research Progress on COVID-19 Vaccine

作　　者：陈静[1] 李波[2] 申硕[3] 范亚飞 CHEN Jing;LI Bo;SHEN Shuo;FAN Yafei(Medical College of China Three Gorges University,Yichang 443002,China;Affiliated Renhe Hospital of China Three Gorges University,Yichang 443003,China;Laboratory I of Viral Vaccine,Wuhan Institute of Biological Products,Wuhan 430207,China;BACME Biotech Co.,Ltd,Suzhou 215434,China)

机构地区：[1]三峡大学医学院,宜昌443002 [2]三峡大学附属仁和医院,宜昌443003 [3]武汉生物制品研究所病毒性疫苗研究一室,武汉430207 [4]苏州华益美生物科技有限公司,苏州215434

出　　处：《病毒学报》2020年第4期685-691,共7页Chinese Journal of Virology

基　　金：湖北省知识创新专项(项目号:2019CFC865),题目:柯萨奇病毒A6病毒样颗粒的免疫原性及保护性研究;湖北省技术创新专项(重大项目,项目号:141),题目:手足口病双价灭活疫苗的研制;国家“重大新药创制”科技重大专项(项目号:2015ZX09102021),题目:人肠道病毒71型及柯萨奇病毒A16型双价灭活疫苗的研制;三峡大学人才专项经费(项目号:20171227)。

摘　　要：新型冠状病毒肺炎(Coronavirus disease 2019,COVID-19)是由新型冠状病毒(Severe acute respiratory syndrome coronavirus 2,SARS-CoV-2)引起的一种新的传染病。阻止COVID-19流行最有效的方法就是研制安全有效的疫苗,目前国内外多家机构开展了COVID-19疫苗的研究,包括核酸疫苗、病毒载体疫苗、灭活疫苗、重组蛋白疫苗、减毒流感病毒载体疫苗等不同类型,并取得了快速进展。本文对COVID-19疫苗的类型、研究进展、存在的问题等进行综述。Coronavirus disease 2019(COVID-19)is a new infectious disease caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).The most effective way to prevent the COVID-19 pandemic sweeping the world is to develop safe and effective vaccines.Many institutions have carried out research on different types of vaccines such as nucleic acid vaccine,viral vector vaccine,inactivated vaccine,recombinant protein vaccine,and attenuated influenza virus vector vaccine,and have made inspiring progress.We reviewed the research progress for different types of COVID-19 vaccine,and analyzed existing problems with their development.

关 键 词：新型冠状病毒肺炎 2019新型冠状病毒 疫苗 

分 类 号：R183.3[医药卫生—流行病学]