利咽散结方对阻塞性睡眠呼吸暂停低通气综合征合并原发性高血压患者睡眠呼吸暂停低通气指数、最低血氧饱和度及动态血压的影响  

Effect of Liyan Sanjie recipe on ambulatory blood pressure,sleep apnea hypopnea index and the lowest oxygen saturation in patients with obstructive sleep apnea hypopnea syndrome complicated with essential hypertension

作　　者：王强[1] 申雪娜 来于[1] 高慧[1] 孙侃[1] 胡筱冉 WANG Qiang;SHEN Xuena;lai Yu(The Third Department of Cardiology,Shijiazhuang Hospital of Traditional Chinese Medicine,Shijiazhuang,Hebei 050051;不详)

机构地区：[1]河北省石家庄市中医院心三科,河北石家庄050051 [2]河北中医学院研究生学院,河北石家庄050091 [3]中国人民解放军河北省军区石家庄第八离职干部休养所,河北石家庄050011

出　　处：《河北中医》2020年第5期661-665,671,共6页Hebei Journal of Traditional Chinese Medicine

基　　金：河北省科学技术厅2017年度省级科技计划项目(编号:17277788D)。

摘　　要：目的观察利咽散结方对阻塞性睡眠呼吸暂停低通气综合征(OSAHS)合并原发性高血压患者睡眠呼吸暂停低通气指数(AHI)、最低血氧饱和度(LSaO 2)及动态血压的影响。方法将90例OSAHS合并原发性高血压患者按照随机数字表法分为2组。对照组45例予苯磺酸氨氯地平片治疗,治疗组45例在对照组治疗基础上加用利咽散结方。2组均治疗12周。比较2组治疗前后中医症状评分变化,比较2组治疗前后AHI、LSaO 2及动态血压变化。结果2组治疗后AHI较本组治疗前降低(P<0.05),LSaO 2较本组治疗前升高(P<0.05),且治疗后治疗组AHI低于对照组(P<0.05),LSaO 2高于对照组(P<0.05)。2组治疗后24 h平均收缩压(24 hSBP)、24 h平均舒张压(24 hDBP)、日间平均收缩压(dMSP)、日间平均舒张压(dMDP)、夜间平均收缩压(nMSP)、夜间平均舒张压(nMDP)均较本组治疗前降低(P<0.05),24 h收缩压平滑指数(24 hSIS)、24 h舒张压平滑指数(24 hSID)、日间收缩压平滑指数(dSIS)、日间舒张压平滑指数(dSID)、夜间收缩压平滑指数(nSIS)、夜间舒张压平滑指数(nSID)均较本组治疗前升高(P<0.05),且治疗后治疗组24 hSBP、24 hDBP、nMSP及nMDP均低于对照组(P<0.05),24 hSIS、24 hSID、nSIS及nSID均高于对照组(P<0.05)。2组治疗后各中医症状评分均较本组治疗前降低(P<0.05),且治疗组降低更明显(P<0.05)。结论利咽散结方治疗OSAHS合并原发性高血压,能明显改善中医症状,改善睡眠呼吸暂停低通气,提高血氧饱和度,降低血压,延缓病情进展。Objective To observe the effect of Liyan Sanjie recipe on ambulatory blood pressure,sleep apnea hypopnea index(AHI)and the lowest oxygen saturation(LSaO 2)in patients with obstructive sleep apnea hypopnea syndrome(OSAHS)complicated with essential hypertension.Methods 90 OSAHS patients with essential hypertension were randomly divided into two groups according to the random number table method.45 cases in control group were treated by amlodipine besylate tablets.45 cases in treatment group were treated by Liyan Sanjie recipe on the basis of the control group.Both groups were treated for 12 weeks.The changes of TCM symptom scores,ambulatory blood pressure,AHI and LSaO2 were compared between the two groups before and after treatment.Results After treatment,AHI in both groups was lower than that in the group before treatment(P<0.05),and LSaO 2 was higher than that before treatment in this group(P<0.05);AHI in treatment group was lower than that in control group(P<0.05),and LSaO2 was higher than that in control group(P<0.05).After treatment,the 24 h mean systolic blood pressure(24 hSBP),24 h mean diastolic blood pressure(24 hDBP),daytime mean systolic blood pressure(dMSP),daytime mean diastolic blood pressure(dMDP),night mean systolic blood pressure(nMSP)and nighttime mean diastolic blood pressure(nMDP)in the two groups were lower than those in the group before treatment(P<0.05).After treatment,24 h systolic blood pressure smoothing index(24 hSIS),24 h diastolic blood pressure smoothing index(24 hSID),daytime systolic blood pressure smoothing index(dSIS),daytime diastolic blood pressure smoothing index(dSID),night systolic blood pressure smoothing index(nSIS),night diastolic blood pressure smoothing index(nSID)were all higher than those in the group before treatment(P<0.05).After treatment,24 h SBP,24 h DBP,nMSP and nMDP in the treatment group were lower than those in the control group(P<0.05),24 hSIS,24 hSID,nSIS and nSID in the treatment group were higher than those in the control group(P<0.05).After treatment,the s

关 键 词：睡眠呼吸暂停综合征 高血压 中药疗法 

分 类 号：R338.63[医药卫生—人体生理学] R544.1[医药卫生—基础医学]