经皮冠状动脉介入治疗冠心病的临床效果及对患者血清VEGF水平的影响  

Clinical Effect of Percutaneous Coronary Intervention on Coronary Heart Disease and its Influence on Serum VEGF Level

作　　者：刘许增[1] 余新东[1] 罗才福[1] 何显荣[1] 刘洋 LIU Xu-zeng;YU Xin-dong;LUO Cai-fu(Gaoming District People's Hospital of Foshan City,Foshan Guangdong 528500)

机构地区：[1]佛山市高明区人民医院,广东佛山528500

出　　处：《医学临床研究》2020年第7期1042-1044,共3页Journal of Clinical Research

摘　　要：【目的】探讨经皮冠状动脉介入(PCI)治疗冠心病(CHD)的临床效果及对血清血管内皮生长因子(VEGF)水平的影响。【方法】本回顾性分析2017年1月至2019年1月本院收治的92例CHD患者的临床资料,根据治疗方法的不同将其分为观察组和对照组,每组各46例。对照组患者行保守治疗方式,观察组在对照组的基础上行PCI术进行治疗。比较两组患者的治疗有效率、心功能指标[收缩末期内径(LVESD)、舒张末期内径(LVEDD)、左心室射血分数(LVEF)、B型脑钠肽(BNP)]、治疗前后的VEGF水平以及治疗后的不良心血管事件发生率。【结果】观察组治疗有效率为95.65%(44/46),显著高于对照组的80.43%(37/46),差异有统计学意义(χ2=5.061,P=0.023<0.05)。治疗后,两组LVESD、LVEDD及血清BNP水平均低于治疗前,LVEF高于治疗前,且两组比较差异均有统计学意义(P<0.05)。术后即刻,观察组血清VEGF水平高于对照组,治疗后48 h及1周观察组血清VEGF水平低于对照组,差异有统计学意义(P<0.05)。随访3个月,观察组不良心血管发生率为0,低于对照组的15.22%(7/46),差异有统计学意义(χ2=5.572,P=0.018<0.05)。【结论】CHD患者行PCI术治疗具有较好的临床效果,且能够降低VEGF水平,可较好的改善患者心功能,值得临床借鉴。【Objective】To investigate the clinical effect of percutaneous coronary intervention(PCI)in the treatment of coronary heart disease(CHD)and its effect on serum vascular endothelial growth factor(VEGF).【Methods】The clinical data of 92 patients with CHD admitted to our hospital from January 2017 to January 2019 were retrospectively analyzed,and they were divided into observation group and control group according to different treatment methods,with 46 cases in each group.The control group received conservative treatment,while the observation group received PCI on the basis of the control group.The treatment efficiency,cardiac function indexes(LVESD,LVEDD,LVEF,BNP),VEGF levels before and after treatment and the incidence of adverse cardiovascular events were compared between the two groups.【Results】The effective rate of the observation group was 95.65%(44/46),which was significantly higher than 80.43%(37/46)of the control group(χ2=5.061,P=0.023<0.05).After treatment,LVESD,LVEDd and serum BNP levels in the two groups were lower than those before treatment,and LVEF was higher than that before treatment,and the differences between the two groups were statistically significant(P<0.05).Immediately after operation,the serum VEGF level of the observation group was higher than that of the control group,and the serum VEGF level of the observation group was lower than that of the control group 48 h and 1 week after treatment,the difference was statistically significant(P<0.05).After 3 months of follow-up,the incidence of adverse cardiovascular events in the observation group was 0,which was lower than 15.22%(7/46)of the control group(χ2=5.572,P=0.018<0.05).【Conclusion】CHD patients with PCI treatment has a good clinical effect,and can reduce the level of VEGF,can better improve the cardiac function of patients,worthy of clinical reference.

关 键 词：冠心病 血管成形术 气囊 冠状动脉 血管内皮生长因子A 

分 类 号：R541.4[医药卫生—心血管疾病]