双胍类药物对老年T2DM患者肠道菌群及糖脂代谢水平的影响  

Effects of Biguanides on Intestinal Flora and Glucose and Lipid Metabolism in Elderly Patients with T2DM

作　　者：许先锋 XU Xian-feng(Changsha hospital of traditional Chinese medicine,Hunan Changsha 410100)

机构地区：[1]长沙市中医医院/长沙市第八医院,湖南长沙410100

出　　处：《医学临床研究》2020年第7期1048-1050,共3页Journal of Clinical Research

摘　　要：【目的】探讨双胍类药物对老年2型糖尿病(T2DM)患者肠道菌群及糖脂代谢水平的影响。【方法】选取2018年1月至2019年6月在本院治疗的老年T2DM患者150例,按照随机数表法分为观察组和对照组,观察组患者服用二甲双胍,对照组患者服用安慰剂。比较两组患者治疗前后肠道菌群变化、炎性指标水平及代谢情况。【结果】两组患者治疗前肠道菌群数量比较差异无统计学意义(P>0.05);治疗后,观察组患者有益菌双歧杆菌、乳酸杆菌数量明显增加,而有害菌肠杆菌、肠球菌数量明显下降(P<0.05);两组患者治疗前空腹血糖(FPG)、餐后2 h血糖(2hPG)、三酰甘油(TG)、C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)水平比较差异无统计学意义(P>0.05);治疗后,观察组患者FPG、2hPG、TG、CRP、TNF-α水平均明显低于对照组,其差异均有统计学意义(P<0.05)。【结论】双胍类药物可较好的纠正老年T2DM患者肠道菌群失衡,增加有益菌群的数量,降低有害菌群数量,纠正代谢紊乱,值得临床推广使用。【Objective】To investigate the clinical effect of biguanides on intestinal flora imbalance and metabolic disorder in elderly patients with T2DM.【Methods】A total of 150 elderly patients with T2DM who were treated in our hospital from January 2018 to June 2019 were selected and randomly divided into observation group and control group.The observation group was given metformin,and the control group was given placebo.The changes of intestinal flora,inflammatory indexes and metabolism of the two groups were compared before and after treatment.【Results】Between the two groups,there was no significant difference in the number of intestinal flora before treatment(P>0.05);After treatment,The number of Bifidobacterium and Lactobacillus increased significantly in the observation group,However,the number of Enterobacter and Enterococcus were significantly decreased(P<0.05);There was no significant difference in fasting blood glucose(FPG),postprandial 2h glucose(2hPG),triacylglycerol(TG),C-reactive protein(CRP),tumor necrosis factor between the two groups(P>0.05);After treatment,All the FPG、2hPG、TG、CRP、TNF-αlevels in the observation group were significantly lower than those in the control group,All the differences were statistically significant(P<0.05).【Conclusion】Biguanides can better correct the imbalance of intestinal flora in elderly patients with T2DM,increase the number of beneficial bacteria,reduce the number of harmful bacteria,and correct metabolic disorders,which is worthy of clinical application.

关 键 词：糖尿病 2型 肠/微生物学 

分 类 号：R587.1[医药卫生—内分泌]