模拟生物体液中污染物生物可利用性研究进展  

Assessment of pollutants bioaccessibility in simulated body fluids using in vitro tests:a review

作　　者：董慧 肖保华[3] 邸欣月[3] 安显金 汤海明 DONG Hui;XIAO Baohua;DI Xinyue;AN Xianjin;TANG Haiming(School of Karst Science,Guizhou Normal University,Guiyang Guizhou 550002;State Engineering Technology Institute for Karst Desertification Control,Guiyang Guizhou 550002;State Key Laboratory of Environmental Geochemistry,Institute of Geochemistry,Chinese Academy of Sciences,Guiyang Guizhou 550002;College of Basic Medicine,Guizhou University of Traditional Chinese Medicine,Guiyang Guizhou 550025)

机构地区：[1]贵州师范大学喀斯特研究院,贵州贵阳550002 [2]国家喀斯特石漠化防治工程技术研究中心,贵州贵阳550002 [3]中国科学院地球化学研究所,环境地球化学国家重点实验室,贵州贵阳550002 [4]贵州中医药大学基础医学院,贵州贵阳550025

出　　处：《环境污染与防治》2020年第8期1039-1043,1059,共6页Environmental Pollution & Control

基　　金：国家自然科学基金资助项目(No.41173129、No.41273149);贵州省国内一流学科建设项目(黔教科研发〔2017〕85号);贵州省熊康宁“喀斯特环境”研究生导师工作室项目(黔教研合GZS字〔2016〕04号);2018年贵州师范大学博士科研项目(贵州师范大学〔2018〕29号)。

摘　　要：模拟生物体液实验是一种评估有毒物质(包括有机污染物和无机污染物)对人体危害的重要手段,该方法通过模拟人体消化及呼吸等过程评估经各种暴露途径进入人体的污染物的生物可利用性。综述了近年来在污染物生物可利用性领域所取得的最新研究进展,介绍了模拟生物体液实验建立的背景,分析了影响污染物生物可利用性的主要因素,最后对现阶段利用模拟胃肠液及肺液估算污染物生物可利用性的研究方向进行了展望。In vitro test is an important tool when assessing the human-health risk from toxic substances,including toxic organic pollutants and inorganic pollutants.The approach seeks to mimic the processes of human digestion and inhalation,then assess the bioaccessibility of pollutants from environmental media via several exposure pathways.In this paper,the latest research progress in the field of bioaccessibility of pollutants is reviewed,including introducing the background of in vitro tests and analyzing the main factors affecting the bioaccessibility of pollutants.Finally,the perspectives for future researches in the area of bioaccessibility of pollutants using simulated gastrointestinal fluids and lung fluids were discussed.

关 键 词：模拟胃肠液 模拟肺液 生物可利用性 

分 类 号：X503.1[环境科学与工程—环境工程]