香菊胶囊对分泌性中耳炎的疗效及对咽鼓管表面活性物质含量的影响  

Efficacy of Xiangju Capsules on secretory otitis media and its impact on eustachian tube surfactant content

作　　者：谢华[1] XIE Hua(Department of Otolaryngology-Head and Neck Surgery,Liuzhou People′s Hospital,Liuzhou 545006,China)

机构地区：[1]广西柳州市人民医院耳鼻咽喉头颈外科,柳州市545006

出　　处：《广西医学》2020年第14期1821-1823,1835,共4页Guangxi Medical Journal

基　　金：广西壮族自治区中医药管理局科研课题(GZZC13-31);广西医药卫生科研课题(Z2013659)。

摘　　要：目的探讨香菊胶囊对分泌性中耳炎(SOM)的疗效及对咽鼓管表面活性物质(ETS)含量的影响。方法将120例(159耳)SOM患者随机分为A组(41耳)、B组(39耳)、C组(37耳)、D组(42耳)各30例。所有患者给予鼓室注射地塞米松,A组加用香菊胶囊,B组加用盐酸氨溴索片,C组加用香菊胶囊和盐酸氨溴索片,D组不加其他治疗。比较4组患者治疗前和治疗后第2周末、第4周末、第12周末的咽鼓管通畅情况和鼓室积液中ETS含量。结果治疗后第2周末,C组咽鼓管通畅率高于B组和D组(P<0.05);治疗后第4周末、第12周末,C组咽鼓管通畅率高于其他3组(P<0.05),A组、B组咽鼓管通畅率高于D组(P<0.05),而A组与B组之间差异无统计学意义(P>0.05)。患者鼓室积液中卵磷脂水平随时间延长而升高(P<0.05),其中治疗后各时点A组、C组卵磷脂水平均高于B组、D组(P<0.05),但A组与C组之间、B组与D组之间卵磷脂水平无统计学差异(P>0.05)。结论在鼓室注射地塞米松的基础上,应用香菊胶囊与氨溴索联合治疗可进一步改善SOM患者的咽鼓管通畅程度,促进ETS的分泌,有助于患者早日康复。Objective To investigate the efficacy of Xiangju Capsules on secretory otitis media(SOM)and its impact on eustachian tube surfactant(ETS)content.Methods A total of 120 patients(159 ears)with SOM were randomly divided into groups A(41 ears),B(39 ears),C(37 ears)and D(42 ears),with 30 cases in each group.All the patients were injected dexamethasone in tympanum,group A received additional Xiangju Capsules,group B received additional Ambroxol Hydrochloride Tablets,group C received additional Xiangju Capsules and Ambroxol Hydrochloride Tablet,and group D did not receive any other treatment.Eustachian tube patency and ETS content in tympanic cavity effusion were compared among the four groups before treatment,and the end of the second week,the forth week and the 12th week after treatment.Results At the end of the second week after treatment,group C had higher eustachian tube patency rate than group B or D(P<0.05);at the end of the forth or 12th week after treatment,group C exhibited higher eustachian tube patency rate than the other three groups(P<0.05),group A or B exhibited higher eustachian tube patency rate than group D(P<0.05),but no statistically significant difference was found between group A and group B(P>0.05).The level of lecithin in tympanic cavity effusion increased with time in the patients(P<0.05),group A or C had higher lecithin level than group B or D at all time points after treatment(P<0.05),however,there was no statistically significant difference in lecithin level between group A and group C,or between group B and group D(P>0.05).Conclusion Based on intratympanic injection of dexamethasone,combined therapy of Xiangju Capsules and ambroxol can further improve eustachian tube patency and promote ETS secretion in SOM patients,which is conductive to patients′recovery as soon as possible.

关 键 词：分泌性中耳炎 香菊胶囊 地塞米松 氨溴索 咽鼓管通畅 表面活性物质 

分 类 号：R764.21[医药卫生—耳鼻咽喉科]