头低位卧床对恒河猴骨代谢、糖脂代谢的抑制效应及其相关性分析  

Inhibitory Effects of Head-down Bed Rest on Bone,Glycolipid Metabolism of Rhesus and Their Correlation Analysis

作　　者：杨超[1] 徐子涵 李铠 张洪玉[1] 王海龙 吴峰[1] 曹宏卿[1] 阚广捍[1] 李莹辉[1,2] 戴钟铨 YANG Chao;XU Zihan;LI Kai;ZHANG Hongyu;WANG Hailong;WU Feng;CAO Hongqing;KAN Guanghan;LI Yinghui;DAI Zhongquan(State Key Laboratory of Space Medicine Fundamentals and Application,Astronaut Center of China,Beijing 100094;School of Life Science and Technology,Harbin Institute of Technology,Harbin 150001)

机构地区：[1]中国航天员科研训练中心航天医学基础与应用国家重点实验室,北京100094 [2]哈尔滨工业大学生命科学与技术学院,哈尔滨150001

出　　处：《空间科学学报》2020年第4期540-546,共7页Chinese Journal of Space Science

基　　金：青年人才托举工程项目(2015-2017-2015QNRC001);国家自然科学基金项目(81801872,31470832,31570858);国家重大科学仪器设备开发专项(2013YQ190467);中国航天员科研训练中心航天医学基础与应用国家重点实验室自主科研项目(SYFD1500604)共同资助。

摘　　要：空间失重引起的骨代谢调节失衡是航天员遭受的最严重的危害之一.骨代谢失衡还有可能影响机体的糖脂代谢平衡.本研究利用恒河猴头低位卧床模拟失重效应实验方法,分析头低位卧床过程中恒河猴血清中骨代谢、糖脂代谢指标变化情况及其相关性.卧床组恒河猴血清中BAP在头低位卧床实验开始7天便出现了显著下降(P<0.05),血清胰岛素、高密度脂肪酸含量在7天显著下降并一直维持在较低水平,血糖含量在7天时显著下降,但在21天时明显回升.分析发现,骨钙素与血糖、皮质醇、高密度脂肪酸含量间均存在相关性,这表明头低位卧床模拟失重效应实验中骨与糖脂代谢之间存在相互调控.Bone loss and subclinical diabetes-like are developed during long-term spaceflight.Recently,it was demonstrated that bone was able to regulate energy metabolism and testosterone synthesis via osteocalcin.In this study,we analyzed the changes of bone metabolism and glycolipid metabolism of rhesus and their association(P<0.05).Serum insulin and LDL content significantly decreased at 7 days and remained at a low level,and the blood glucose level showed a significant decline at 7 days,but recovery at 21 days.The correlation analysis showed that there was a correlation between osteocalcin and blood glucose,cortisol and HDL.The experimental results show that there is mutual regulation between bone and glycolipid metabolism in the bedrest experiment of rhesus.

关 键 词：恒河猴 卧床实验 骨钙素 糖脂代谢 

分 类 号：R85[医药卫生—航空、航天与航海医学]