通窍平喘方治疗儿童过敏性鼻炎-哮喘综合征临床疗效及对血清IgE、EOS的影响  

Clinical efficacy of Tongqiao Pingchuan Formula on combined allergic rhinitis and asthma syndrome in children and its effects on serum IgE and EOS

作　　者：武明云 虞坚尔[1,3] 薛征[1,2] 白莉[1,3] 吴杰[1,3] 蒋沈华 徐万超[1,2] WU Mingyun;YU Jian'er;XUE Zheng;BAI Li;WU Jie;JIANG Shenhua;XU Wanchao(Municipal Hospital of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200071,China;Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Institute of Traditional Chinese Medicine Pediatrics,Shanghai Academy of Traditional Chinese Medicine,Shanghai 200071,China)

机构地区：[1]上海中医药大学附属市中医医院,上海200071 [2]上海中医药大学,上海201203 [3]上海市中医药研究院中医儿科研究所,上海200071

出　　处：《上海中医药大学学报》2020年第4期21-26,共6页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(81603662);上海市中医药事业发展三年行动计划项目[ZY(2018-2020)-CCCX-1012];上海市名老中医学术经验研究工作室建设项目(SHGZS-2017001)。

摘　　要：目的:评价通窍平喘方治疗儿童过敏性鼻炎-哮喘综合征(CARAS)的临床疗效及对患儿血清免疫球蛋白E(IgE)、外周血嗜酸性粒细胞计数(EOS)的影响。方法:将符合纳入标准的96例CARAS患儿按照随机数字表法分为对照组和观察组,每组各48例。对照组采用布地奈德+孟鲁司特钠联合治疗,观察组在对照组的基础上加用通窍平喘方治疗,疗程均为14 d。观察治疗前后两组患儿CARAS临床症状评分、第1秒用力呼气量(FEV1)与呼气峰流速(PEF)变化,评价临床疗效及中医证候疗效;检测血清EOS和IgE表达水平。结果:治疗后,两组主症积分相比,观察组喘息和咳嗽症状积分低于对照组(P<0.01),观察组喷嚏、鼻塞、鼻痒、流涕等鼻炎症状积分低于对照组(P<0.01);次症积分相比,观察组在面色、咽痒、耳痒、眼痒、鼻黏膜的症状积分低于对照组(P<0.01);观察组的总积分明显低于对照组(P<0.01)。对照组总有效率为70.0%,观察组总有效率为90.4%,观察组的总疗效优于对照组(P<0.01)。观察组肺功能FEV1和PEF的改善程度优于对照组(P<0.01),观察组EOS和IgE水平低于对照组(P<0.01)。结论:通窍平喘方可有效改善CARAS患儿的气道炎症与气道重建,调节免疫功能,缓解症状与体征,值得临床推广与应用。Objective:To evaluate the clinical efficacy of Tongqiao Pingchuan Formula on children with combined allergic rhinitis and asthma syndrome(CARAS)and its effects on serum immunoglobulin E(IgE)and eosinophil(EOS)count in peripheral blood.Methods:Ninety-six children with CARAS who met the inclusion criteria were randomly divided into the control group and observation group according to the random number table,48 cases in each group.The control group was treated with budesonide combined with montelukast sodium,and the observation group was treated with Tongqiao Pingchuan Formula based on the treatment for the control group,with a course of 14 days.Before and after treatment,the clinical symptoms scores of CARAS,forced expiratory volume in one second(FEV1)and peak expiratory flow(PEF)were measured,the clinical efficacy and the efficacy of Chinese medical syndrome were evaluated,and the serum levels of IgE and EOS were detected.Results:After treatment,in main symptom scores of asthma,the symptom scores of wheezing and coughing in the observation group were lower than those in the control group(P<0.01);in main symptom scores of rhinitis,the symptom scores of sneezing,stuffy nose,itchy nose and runny nose in the observation group were lower than those in the control group(P<0.01).In secondary symptom scores,the symptom scores of face color,itching in pharynx,itching in ear,itching in eye and nasal mucosa in the observation group were lower than those in the control group(P<0.01).The total score of the observation group was significantly lower than that of the control group(P<0.01).The total effective rate of the control group was 70.0%,and the total effective rate of the observation group was 90.4%.The total efficacy of the observation group was better than that of the control group(P<0.01).The improvement on lung function FEV1 and PEF in the observation group was better than that in the control group(P<0.01),and the levels of EOS and IgE in the observation group were lower than those in the control group(P<0.01).Conclusi

关 键 词：过敏性鼻炎-哮喘综合征 通窍平喘方 临床疗效 IgE EOS 中医药疗法 

分 类 号：R272[医药卫生—中医儿科学]