基于复杂网络技术和点式互信息分析慢性肾脏病本虚标实证中药配伍规律  

Compatibility rules of prescriptions for the treatment of chronic kidney disease with deficiency of root and excess of secondary condition based on complex network technology and point-to-point mutual information analysis

作　　者：王世琤[1] 杜华 张宁[1] WANG Shi-cheng;DU Hua;ZHANG Ning

机构地区：[1]中国中医科学院望京医院肾病内分泌科,北京100102

出　　处：《北京中医药》2020年第6期548-552,共5页Beijing Journal of Traditional Chinese Medicine

基　　金：首都卫生发展科研专项重点攻关项目(首发2018-1-4161)。

摘　　要：目的通过复杂网络技术和点式互信息分析慢性肾脏病(CKD)患者的中医处方,探讨CKD治疗中医用药规律和核心处方。方法选择2014年1月1日—2016年12月31日中国中医科学院望京医院张宁教授诊治的CKD患者860例的首诊中医处方信息,对中药名称进行规则化处理,导入Liquorice软件,以同质网络创建关系数据,进行复杂网络分析和点式互信息分析。结果用药频度、强度较高的药物有黄芪、丹参、生薏苡仁、茯苓、石韦、柴胡、酒大黄、地龙、当归、白芍、炒枣仁、狗脊、白茅根、生地黄等;核心处方为黄芪、当归、白芍、柴胡、炒酸枣仁、丹参、地龙、茯苓、生薏苡仁、白茅根、石韦、酒大黄;张教授治疗CKD以益气养血、活血化瘀、利湿泻浊为主要治则。结论脾肾两虚、浊瘀互阻是CKD病机,固本泻浊的主要治则与张教授临床思路一致,可应用于CKD全疗程;复杂网络技术和点式互信息分析适用于总结中医用药规律和核心处方。Objective To explore the rules of using Chinese herbal medicines and core prescriptions for chronic kidney disease(CKD)through analyzing TCM prescriptions for CKD patients with complex network technology and point-to-point mutual information.Methods The prescriptions made by Prof.ZHANG Ning for 860 cases CKD patients in their first visits from January 1,2014 to December 31,2016 in Wangjing Hospital of the China Academy of Chinese Medical Sciences were collected.The names of Chinese herbal medicines were regularized,and then induced into Liquorice software to create relational data with homogeneous networks with complex network and point mutual information analysis.Results The drugs used with higher frequency and intensity were Astragali Radix,Salviae Miltiorrhizae Radix Et Rhizoma,Coicis Semen,Poria,Pyrrosiae Folium,Bupleuri Radix,liquor processed Rhei Radix Et Rhizoma,Pheretima,Angelicae Sinensis Radix,Paeoniae Radix Alba,parched wild jujube seed,Cibotii Rhizoma,Imperatae Rhizoma,and Rehmanniae Radix.,and the core prescriptions were Astragali Radix,Salviae Miltiorrhizae Radix Et Rhizoma,Coicis Semen,Poria,Pyrrosiae Folium,Bupleuri Radix,liquor processed Rhei Radix Et Rhizoma,Pheretima,Angelicae Sinensis Radix,Paeoniae Radix Alba,and Cibotii Rhizoma.The basic principles of treatment were nourishing qi and blood,promoting blood circulation to dispel blood stasis and clearing damp and purging the turbid.Conclusion Spleen and kidney deficiency and the mutual blockage of turbidity and stasis are the pathogenesis of CKD.The treatment principle of reinforcing the root and purging the turbid is consistent with the clinical thinking of Prof.ZHANG which can be used in the whole the treatment of CKD.Complex network analysis and point mutual information analysis could be applied for summarizing the rules of using herbal medicines and making core precipitations.

关 键 词：慢性肾脏病 固本泻浊法 数据挖掘 核心处方 

分 类 号：R277.5[医药卫生—中医学]