原发性肾病综合征患儿院内感染病原菌类型、发生因素logistic分析及多元化干预措施效果的研究  

Logistic analysis of pathogenic bacteria types and occurrence factors of nosocomial infection in children with primary nephritic syndrome and the effect of diversified intervention measures

作　　者：李紫薇 林丽丽[2] 姜明宇[1] Li Ziwei;Lin Lili;Jiang Mingyu(Department of Pediatrics,the First Affiliated Hospital of Haerbin Medical University,Haerbin 150001,China;Department of Ophthalmology,the First Affiliated Hospital of Haerbin Medical University,Haerbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第一医院儿内科,哈尔滨150001 [2]哈尔滨医科大学附属第一医院眼科,哈尔滨150001

出　　处：《国际泌尿系统杂志》2020年第4期668-672,共5页International Journal of Urology and Nephrology

基　　金：黑龙江省卫生计生委科研课题(2017006)。

摘　　要：目的分析原发性肾病综合征(PNS)患儿院内感染病原菌类型及影响因素,探讨多元化干预措施效果。方法将2016年4月至2018年12月在本院收治的100例PNS患儿随机分为观察组和对照组。对照组采用常规方案干预,观察组采用多元化措施干预,记录两组患者满意率、生活质量及感染率,并分析两组患者病原菌类型及影响因素。结果治疗后观察组患者血中白蛋白水平明显高于对照组,IL-6水平明显低于对照组,且差异有统计学意义(P<0.05);观察组患者满意度明显高于对照组,且差异有统计学意义(P<0.05);干预后两组患者SF-36各维度评分均显著升高(P<0.05),且观察组生活质量量表各维度评分显著高于对照组(P<0.05);对照组患儿感染率显著高于观察组(P<0.05),且两组患儿革兰阴性菌感染率最高;侵入性操作及白蛋白水平是导致PNS患儿院内感染的独立性危险因素(P<0.05)。结论PNS患儿采用多元化模式干预后可显著提高患儿满意度及生活质量,并降低感染率,且白蛋白水平及住院时间是影响PNS患儿院内感染的独立性危险因素。Objective To analyze the types and influencing factors of nosocomial infection pathogens in children with PNS,and to explore the effects of diversified interventions.Methods From April 2016 to December 2018,100 children with PNS in our hospital were randomly divided into observation group and control group.The control group was intervened by routine program,while the observation group was intervened by diversified measures.Satisfaction rate,quality of life and infection rate of the two groups were recorded,and the types and effects of pathogens of the two groups were analyzed.Results After treatment,the serum albumin level in the observation group was significantly higher than that in the control group,and the level of IL-6 was significantly lower than that in the control group(P<0.05).The nursing satisfaction of the observation group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).After nursing,the scores of SF-36 dimensions in the two groups were significantly increased(P<0.05),and the scores of each dimension of the quality of life scale in the observation group were significantly higher than those in the control group(P<0.05).The infection rate in the control group was significantly higher than that in the observation group(P<0.05),and the infection rate of Gram-negative bacteria in the two groups was the highest.Invasive operation and albumin level were independent risk factors for nosocomial infection in children with PNS(P<0.05).Conclusions PNS children can significantly improve their nursing satisfaction and quality of life,and reduce the infection rate,and the level of albumin and hospitalization time are independent risk factors of nosocomial infection in PNS children.

关 键 词：肾病综合征 儿童 交叉感染 多元化干预 

分 类 号：R726.9[医药卫生—儿科]