12种中药注射剂与4种常用输液连续滴注后混合液的稳定性考察  

Study on Stability of 12 Kinds of Traditional Chinese Medicine Injections and 4 Kinds of Common Solution after Continuous Infusion

作　　者：赵飞燕 王晟 秦媛媛 沈夕坤[1] ZHAO Fei-yan;WANG Sheng;QIN Yuan-yuan;SHEN Xi-kun(Suzhou Hospital Affiliated to Nanjing University of Traditional Chinese Medicine,Suzhou Jiangsu 215009,China;Cardiovascular laboratory,Wuxi Medical School of Jiangnan University,Wuxi Jiangsu 214000,China)

机构地区：[1]南京中医药大学苏州附属医院,江苏苏州215000 [2]江南大学无锡医学院心血管研究室,江苏无锡214000

出　　处：《抗感染药学》2020年第7期933-937,共5页Anti-infection Pharmacy

基　　金：苏州市科技发展计划项目(编号:SYS2019106)。

摘　　要：目的:考察12种中药注射剂与4种常用输液连续滴注后混合液的稳定性,为临床合理、规范和安全使用中药注射剂提供参考。方法:将12种中药注射剂按照说明书要求配制成静脉输液,与不同输液连续滴注,观察并测定成品输液、连续滴注后混合液的稳定性。结果:成品输液随着放置时间的延长,外观、p H值无明显变化,但不溶性微粒呈增多趋势;连续滴注后混合液的p H值无明显变化,但不溶性微粒数量明显增多;部分注射液与碳酸氢钠连续滴注后,混合液颜色变深。结论:使用中药注射剂应根据其说明书并参考药物主要成分的理化性质选择溶媒,连续滴注时不应将含电解质输液作为间隔液,应使用和前后两药均相容的溶媒作为间隔液且不可长时间放置后再静脉滴注。Objective:To study the stability of 12 kinds of Traditional Chinese Medicine injections and 4 kinds of common solution after continuous infusion,so as to provide a reference for the rational,standard and safe use of Traditional Chinese medicine injections.Methods:According to the instructions,12 kinds of Traditional Chinese Medicine injections were prepared into intravenous infusion,and continuous infusion with different fluids was performed.The stability of the mixture after infusion and continuous infusion was observed and measured.Results:With the prolongation of the time,the appearance and p H value of the infusion did not changed obviously.After continuous infusion,the p H value of the mixture did not changed significantly,and the insoluble particles increased significantly.After continuous infusion of some drugs and sodium bicarbonate,the mixture became darker in color.Conclusion:The solvent should be selected according to the instructions and referring to the physical and chemical properties of the main components of the drug.The electrolyte rehydration solution should not be used as the spacer during continuous infusion.

关 键 词：中药注射剂 常用输液 配伍 连续滴注 配伍禁忌 

分 类 号：R969.2[医药卫生—药理学]