苦刺叶总生物碱的抗溃疡药理作用研究  

Study on Anti-ulcer Pharmacological Action of Total Alkaloids from Leaf of Sophora Viciifolia

作　　者：张明发[1] 沈雅琴[1] 朱自平[1] ZHANG Ming-fa;SHEN Ya-qin;ZHU Zi-ping(Shaanxi Academy of Traditional Chinese Medicine,Xi'an 710003,China)

机构地区：[1]陕西省中医药研究院,西安710003

出　　处：《抗感染药学》2020年第7期937-941,共5页Anti-infection Pharmacy

摘　　要：目的:研究苦刺叶总生物碱的抗溃疡药理作用及其机制,为开发新的抗溃疡药物提供实验依据。方法:采用各种实验性胃溃疡模型,探究苦刺叶总生物碱的抗溃疡作用。结果:苦刺叶总生物碱能抑制水浸应激性小鼠胃溃疡,其半数有效剂量(ED50)为(22.1±16.7)mg/kg;抑制盐酸-乙醇性大鼠胃溃疡,其ED50小于10 mg/kg;能抑制大鼠基础胃液和胃酸的分泌;也能抑制盐酸-牛磺胆酸钠引起大鼠胃溃疡和正密吡唑引起大鼠十二指肠溃疡;但抑制化合物48/80致大鼠胃溃疡的形成不明显。结论:苦刺叶总生物碱具有抗溃疡的作用,有待成为抗溃疡新药。Objective:To study the antiulcer pharmacological actions and mechanisms of total alkaloids from the leaf of Sophora Viciifolia,and to provide experimental basis for developing new antiulcer drugs.Methods:Various experimental gastric ulcer models are used to explore the anti-ulcerous action of Sophora viciifolia alkaloids.Results:Sophora viciifolia alkaloids not only inhibited water-immersion stress-induced gastric ulceration in mice(its ED50 was(22.1±16.7)mg/kg)and HCl-alcohol-induced gastric ulceration in rats(its ED50 was less than 10 mg/kg),but also inhibited excretion of basal gastric juice and gastric acid in rats,HCl-taurocholate-induced gastric ulceration in rats,and meprizole-induced duodenal ulceration in rats.However,Sophora viciifolia alkaloids did not markedly inhibit compound 48/80-induced gastric ulceration in rats.Conclusion:The total alkaloid of Sophora Viciifolia leaf has the function of antiulcer,which will become a new anti-ulcer drug.

关 键 词：白刺花 苦参碱类生物碱 抗溃疡药 

分 类 号：R961[医药卫生—药理学]