Ultra-stable tellurium-doped carbon quantum dots for cell protection and near-infrared photodynamic application  

超稳定的碲掺杂碳量子点在细胞保护和光动力学治疗中的应用

作　　者：Hao Chen Kaikai Wen Jingya Chen Wang Xing Xiaoxi Wu Qinqin Shi Aidong Peng Hui Huang 陈皓;温凯凯;陈静雅;邢旺;吴筱曦;史钦钦;彭爱东;黄辉(Center of Materials Science and Opto-electronic Technology,College of Materials Science and Opto-electronic Technology&CAS Center for Excellence in Topological Quantum Computation&CAS Key Laboratory of Vacuum Physics,University of Chinese Academy of Sciences,Beijing 100049,China;Key Laboratory of Flexible Electronics(KLOFE),Institute of Advanced Materials(1AM),Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM),Nanjing Tech University,Nanjing 211816,China)

机构地区：[1]Center of Materials Science and Opto-electronic Technology,College of Materials Science and Opto-electronic Technology&CAS Center for Excellence in Topological Quantum Computation&CAS Key Laboratory of Vacuum Physics,University of Chinese Academy of Sciences,Beijing 100049,China [2]Key Laboratory of Flexible Electronics(KLOFE),Institute of Advanced Materials(1AM),Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM),Nanjing Tech University,Nanjing 211816,China

出　　处：《Science Bulletin》2020年第18期1580-1586,M0004,共8页科学通报（英文版）

基　　金：the National Natural Foundation of China(21774130 and 51925306);National Key R&D Program of China(2018FYA0305800);the Key Research Program of Frontier Sciences,Chinese Academy of Sciences(QYZDB-SSW-JSC046);Key Research Program of the Chinese Academy of Sciences(XDPB08-2);the Strategic Priority Research Program of Chinese Academy of Sciences(XDB28000000);the International Partnership Program of Chinese Academy of Sciences(211211KYSB20170014);University of Chinese Academy of Sciences。

摘　　要：It is important to regulate the concentration of reactive oxygen species(ROS)in cells since they play important roles in metabolism.Thus,developing nanoreagents to control the ROS is critical.Herein,tellurium-doped carbon quantum dots(Te-CDs)were developed by a simple and efficient hydrothermal method,which can scavenge H2O2 to protect cells under ambient condition,but generateáOH under 808 nm irradiation as photodynamic application.This contribution presented a kind of novel CDs with dual-functions,which can potentially regulate ROS under different conditions.由于活性氧(ROS)在人体新陈代谢中起着重要作用,调节细胞内ROS浓度维持水平是不容忽视的,因此开发能够控制活性氧含量的纳米试剂是非常有意义的.本文采用简单有效的水热法制备了碲掺杂碳量子点(Te-CDs).该量子点水溶性好、稳定性高,具有生物相容性,在溶液水平能够消耗H2O2,在光照下能够产生·OH.因此该碳量子点可作为抗氧化剂应用于细胞保护中,也可作为光敏剂应用于光动力治疗,这双重作用在细胞中均取得了良好的效果,并有望与其他药物共同用于多模态肿瘤治疗.

关 键 词：Reactive oxygen species regulation TELLURIUM Carbon quantum dots Scavenge free-radical Photodynamic effect 

分 类 号：R318.08[医药卫生—生物医学工程] R730.5[医药卫生—基础医学] TB383.1[一般工业技术—材料科学与工程]