基于海洋多糖的纳米给药系统的研究  

Research on Nano-Drug Delivery System Based on Marine Polysaccharide

作　　者：刘晨光[1] 池哲 丁园园 LIU Chen-Guang;CHI Zhe;DING Yuan-Yuan(College of Marine Life Sciences, Ocean University of China, Qingdao 266100, China)

机构地区：[1]中国海洋大学海洋生命学院,山东青岛266100

出　　处：《中国海洋大学学报（自然科学版）》2020年第9期141-152,共12页Periodical of Ocean University of China

基　　金：山东省重点研究发展计划项目(2019GSF107031)资助。

摘　　要：海洋多糖具有来源丰富、生物相容性好、易生物降解、低毒性、低成本、稳定性和安全性高等特点。同时,海洋多糖易于化学改性能够制备满足各种需求的纳米粒(如用于药物递送、基因递送和生物传感等)。因此,海洋多糖是目前被认为用于制备药物递送系统的理想原料。本文综述了海洋多糖的性质、制备海洋多糖纳米粒的主要方法,并从海洋多糖纳米粒的物化性质和结构特征出发讨论几个重要的概念,为临床前和临床应用研究提供依据。然而,目前这类研究大多仍处于实验室阶段,需要进一步进行体内和临床应用研究来开发医用的商品化的纳米产品。Marine polysaccharides are abundant,highly biocompatible,biodegradable,nontoxic,low cost,stable,and safe.In addition,the ease of chemical modification enables the preparation of a wide collection of nanoparticles for a variety of tasks such as drug delivery,gene delivery,and biosensor.Therefore,marine polysaccharides are currently considered as an excellent source for the preparation of drug delivery systems.Here,we will describe the properties of marine polysaccharides and the main mechanisms for marine polysaccharides-based nanoparticles preparation and discuss several key concepts from the physicochemical and structural features of nanoparticles based on marine polysaccharides for pre-clinical and clinical applications.Nevertheless the majority of the commercial applications are still at the laboratory level.Moreover in vivo investigations and clinical applications are required to develop medical commercial nanoproducts.

关 键 词：海洋多糖 药物递送系统 纳米粒 壳聚糖 褐藻胶多糖 

分 类 号：Q539[生物学—生物化学]