矮小儿童血清维生素和微量元素水平及骨龄的相关分析  

Correlation analysis of serum vitamin and trace element levels and bone age in short stature children

作　　者：刘芳[1] 叶静萍[1] 万爱英[1] 刘宏[1] 王高华[1] 王军陵[1] LIU Fang;YE Jingping;WAN Aiying;LIU Hong;WANG Gaohua;WANG Junling(Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院,武汉430060

出　　处：《公共卫生与预防医学》2020年第4期141-144,共4页Journal of Public Health and Preventive Medicine

摘　　要：目的探讨矮小儿童的血清维生素、微量元素水平及与骨龄的相关性。方法对因身高咨询就诊的322例儿童进行血清VA、VD,Ca、Fe、Zn、Mg、Cu、Pb、Cd水平和骨龄的测定,分析骨龄与血清维生素和微量元素水平的相关性。结果322例儿童血清VA、VD缺乏率分别达22.05%、34.16%,Ca、Fe、Zn缺乏率分别达14.29%、21.43%、6.83%,Pb过量率高达42.55%。矮小组的VA水平、VD缺乏率低于偏矮组和正常组,VD水平,VA、Fe缺乏率,Pb过量率均高于偏矮组和正常组。矮小组、偏矮组骨龄(BA)落后率分别为49.38%、37.57%,显著高于正常组,矮小组BA落后儿童的Ca低于BA正常儿童,偏矮组BA落后儿童的VD水平低于BA正常儿童。BA与VD、Ca、Cu水平呈负相关(r=-0.241;r=-0.136;r=-0.162),与Fe呈正相关(r=0.286)。结论矮小儿童存在显著的维生素和微量元素异常,儿童骨龄与体内血清维生素D、钙、铜、铁水平具有一定相关性,应监测儿童体内血清维生素和微量元素水平,指导合理膳食以更好地促进儿童生长发育。Objective To investigate the serum vitamin and trace element levels in children with short stature and their correlation with bone age.Methods Levels of serum VA and VD,and trace elements Ca,Fe,Zn,Mg,Cu,Pb and Cd were measured in 322 children who were referred for height consultation.Bone ages were evaluated and the correlation between bone age and serum vitamin and trace element levels was analyzed.Results The VA and VD deficiency rates of these 322 children were 22.05%and 34.16%,respectively.The deficiency rates of trace elements Ca,Fe and Zn were14.29%,21.43%and 6.83%,respectively.The Pb excess rate was as high as 42.55%.The rates of bone age(BA)retardation in GroupⅠ(short)and GroupⅡ(slightly short)were 49.38%and 37.57%,respectively,which was significantly higher than that of GroupⅢ(normal).The Ca level of BA retardation children was lower than that of the normal BA children in Group I.The VD level of BA retardation children was lower than that of the normal BA children in GroupⅡ.BA was negatively correlated with VD,Ca,and Cu levels in children(r=-0.241;r=-0.136;r=-0.162),and positively correlated with Fe(r=0.286).Conclusion There were significant abnormalities of vitamins and trace elements in short children.Children′s bone age had a certain correlation with serum vitamin D,calcium,copper,and iron levels.Serum vitamin and trace element levels in children should be monitored to guide a reasonable diet to better promote child growth and development.

关 键 词：矮小 儿童 血清维生素 微量元素 骨龄 

分 类 号：R179[医药卫生—妇幼卫生保健]