环磷腺苷葡胺辅助治疗老年人慢性充血性心力衰竭的疗效观察  

Effect of meglumine adenosine cyclic phosphate on chronic congestive heart failure in the elderly

作　　者：汤万胜 岳玉国 赵新国 罗斌斌 刘明芳 Tang Wansheng;Yue Yuguo;Zhao Xinguo;Luo Binbin;Liu Mingfang(Department of Cardiology,Zhejiang Provincial Armed Police Corps Hospital,Jiaxing,Zhejiang 314000,China;Color Doppler Room,Kangjiu Traditional Chinese Medicine Hospital of Jiaxing,Jiaxing,Zhejiang 314000,China)

机构地区：[1]武警海警总队医院心内科,嘉兴314000 [2]嘉兴康久中医院彩超室,浙江省314000

出　　处：《中国基层医药》2020年第13期1601-1604,共4页Chinese Journal of Primary Medicine and Pharmacy

基　　金：浙江省嘉兴市科技计划项目(2017AY33061)。

摘　　要：目的观察环磷腺苷葡胺(MAC)辅助治疗老年人慢性充血性心力衰竭的疗效及其对胱抑素C(CysC)、血浆B型利钠肽(BNP)的影响。方法选择武警海警总队医院2017年8月至2018年8月收治的老年慢性充血性心力衰竭患者110例为观察对象,采用随机数字表法分为对照组55例、观察组55例。对照组采用常规治疗,观察组在常规治疗基础上联合MAC治疗,两组疗程均为2周。比较两组临床疗效及左室射血分数(LVEF)、心输出量、CysC、血浆BNP的变化。结果观察组总好转率为94.55%(52/55),高于对照组的78.18%(43/55),差异有统计学意义(χ^2=6.253,P<0.05)。治疗前,两组LVEF、心输出量、BNP、CysC差异均无统计学意义(均P>0.05);治疗后,观察组LVEF[(44.16±6.82)%]、心输出量[(8.07±1.45)L/min]均明显高于对照组[(40.71±5.38)%、(6.44±1.37)L/min],BNP[(1.65±0.24)mg/L]、CysC[(552.79±10.46)mg/L]均明显低于对照组[(2.31±0.48)mg/L、(681.73±12.71)mg/L],均差异有统计学意义(t=2.945、6.060、9.121、0.551,均P<0.05)。结论MAC辅助治疗老年慢性充血性心力衰竭患者有显著的疗效,可改善患者的心功能,降低血浆CysC、BNP浓度。Objective To observe the efficacy of meglumine adenosine cyclophosphate(MAC)in the adjuvant treatment of chronic congestive heart failure(CHF)in the elderly,and its effects on cystatin C(Cys-C)and plasma B-type natriuretic peptide(BNP).Methods From August 2017 to August 2018,110 elderly patients with chronic CHF admitted to Zhejiang Provincial Armed Police Corps Hospital were selected and randomly divided into control group(55 cases)and observation group(55 cases)by random number table method.The control group was treated with routine treatment,while the observation group was treated with MAC on the basis of routine treatment.Both two groups were treated for 2 weeks.The clinical efficacy,left ventricular ejection fraction(LVEF),cardiac output,Cys-C and plasma BNP were compared between the two groups.Results The total improvement rate of the observation group was 94.55%(52/55),which was higher than 78.18%(43/55)of the control group,the difference was statistically significant(χ^2=6.253,P<0.05).Before treatment,there were no statistically significant differences in LVEF,cardiac output,BNP and Cys-C between the two groups(all P>0.05).After treatment,the LVEF[(44.16±6.82)%],cardiac output[(8.07±1.45)L/min]of the observation group were significantly higher than those of the control group[(40.71±5.38)%,(6.44±1.37)L/min],and BNP[(1.65±0.24)mg/L],Cys-C[(552.79±10.46)mg/L]of the observation group were significantly lower than those of the control group[(2.31±0.48)mg/L,(681.73±12.71)mg/L],the differences were statistically significant(t=2.945,6.060,9.121,0.551,all P<0.05).Conclusion MAC has significant effect in the treatment of elderly patients with chronic CHF.It can improve the cardiac function of patients and reduce the plasma concentrations of Cys-C and BNP.

关 键 词：心力衰竭 环磷腺苷葡胺 化学疗法 辅助 每搏输出量 胱抑素 利钠肽 脑 心室功能 老年人 

分 类 号：R541.6[医药卫生—心血管疾病]