壁冠状动脉周向应力体外加载装置的研制  

Development of an in vitro Loading Device for Circumferential Stress of Mural Coronary Arteries

作　　者：丁皓 刘雨佳[2] 张迎 刘浩宇 阚梦菲 庄逸 杨戈尔 吕杰 DINGHao;LIU Yujia;ZHANG Ying:;LIU Haoyu;KAN Mengfei;ZHUANG Yi;YANG Geer;LU Jie(School of Medical Instrument,Shanghai University of Medicine and Health Sciences,Shanghai 201318,China;School of Medical Instrument and Food Engineering,University of Shanghai for Science and Technology,Shanghai 200093,China)

机构地区：[1]上海健康医学院医疗器械学院,上海201318 [2]上海理工大学医疗器械与食品学院,上海200093

出　　处：《医用生物力学》2020年第3期311-318,共8页Journal of Medical Biomechanics

基　　金：上海市自然科学基金项目(17ZR1413500)。

摘　　要：目的设计并研制壁冠状动脉周向应力体外模拟装置,实现不同程度心肌桥压迫下壁冠状动脉周向应力的体外加载。方法利用心肌桥冠状动脉血液动力学体外模拟装置,实现壁冠状动脉周向应力的体外测量。依托上述实验数据,实现不同程度心肌桥压迫下壁冠状动脉周向应力的体外加载。结果通过体外测量实验发现,壁冠状动脉近心段周向应力最大值、平均值以及波动值都会随着心肌桥压迫程度的增加而显著增大。通过壁冠状动脉周向应力的体外加载实验,验证加载波形与周向应力体外测量实验波形基本吻合。结论该装置可以实现壁冠状动脉周向应力的体外加载,为探究壁冠状动脉近端血液动力学异常对动脉粥样硬化产生及斑块破裂的影响,提供一个尽量接近在体环境、多种参数可调控的体外模拟平台。Objective To design and develop an in vitro simulation device for circumferential stress of mural coronary artery,so as to achieve the in vitro loading of mural circumferential stress under coronary myocardial bridge oppression with different degrees.Methods Using the in vitro simulation device for myocardial bridge coronary artery hemodynamics,the in vitro measurement of mural circumferential stress was achieved.Based on the experimental data,the in vitro loading of mural circumferential stress under coronary myocardial bridge oppression with different degrees was achieved.Results The in vitro measurement experiment showed that the maximum,average and fluctuation of circumferential stress at proximal end of mural coronary artery would increase significantly with the increase in the degree of myocardial bridge oppression.The in vitro loading experiment of mural circumferential stress verified that the loading waveform coincided basically with the experimental waveform from in vitro measurement.Conclusions The device could realize the in vitro loading of mural circumferential stress,which provided an in vitro simulation platform which was as close as possible to the in vivo environment,so as to explore the influence from hemodynamic abnormality of proximal mural coronary artery on the occurrence of atherosclerosis and plaque rupture.

关 键 词：壁冠状动脉 体外加载 周向应力 动脉粥样硬化 

分 类 号：R318.01[医药卫生—生物医学工程]