广州29例境外输入型新型冠状病毒肺炎的临床特点分析  

Analysis of Clinical Characteristics of 29 Cases of Overseas Imported COVID-19 in Guangzhou

作　　者：艾香英[1] 谢敏[1] 林路平[1] 谭行华[1] AI Xiangying;XIE Min;LIN Luping;TAN Xinghua(Guangzhou Eighth People's Hosptial,Guangzhou,Guangdong 510060,China)

机构地区：[1]广州市第八人民医院,广东广州510060

出　　处：《今日药学》2020年第7期442-445,452,共5页Pharmacy Today

基　　金：广东省中医药管理局项目(2020ZYYJ01);广州市医药卫生科技项目(20172A011016)。

摘　　要：目的分析广州境外输入型新型冠状病毒肺炎的临床特点,探讨其临床症状、临床检查结果与病情的相关性,为下一阶段的临床诊治提供指导。方法收集2020年3月11~21日在广州市第八人民医院集中收治的29例境外输入型新型冠状病毒肺炎患者,收集其临床症状、血常规、肝功能、凝血功能、免疫指标、CT等结果,分析上述指标与病情的相关性。结果轻型与普通型患者比较:轻型患者的血清白蛋白(ALB)及CD8^+水平更高(P<0.05),临床症状及其他实验室指标无统计学差异(P>0.05)。CT加重者与非加重者比较:CT加重者的血淋巴细胞计数(LYM)、CD4^+、CD8^+水平更低(P<0.05),降钙素原(PCT)、D-二聚体(D-dimer)水平更高(P<0.05),而超敏C反应蛋白(HPCRP)、C反应蛋白(CRP)虽未见统计学差异,但也是CT加重者高于未加重者;患者的年龄与CT加重亦呈相关性,年龄越大者CT越容易出现加重(P<0.05);两组的临床症状比较,差异无统计学意义(P>0.05)。结论境外输入病例以轻症为主,患者的年龄越大,PCT及D-dimer越高,LYM、ALB、CD4^+、CD8^+越低,提示病情越重,需警惕向重型及危重型进展的可能,而临床症状与病情严重程度不一致,不能作为病情的评估指标。OBJECTIVE To analyze the clinical characteristics of cases of overseas imported Corona Virus Disease 2019(COVID-19)in Guangzhou,and to investigate the correlation between clinical symptoms,clinical examination results,and illness,and to provide guidance for the next stage of clinical diagnosis and treatment.METHODS Twenty-nine patients with overseas imported COVID-19 collected from March 11 th,2020 to March 21 st,2020 in Guangzhou Eighth People’s Hospital were collected,and their clinical symptoms,blood routine,liver function,coagulation function,immune indicators,CT and other results were collected,analysis of the correlation between the above indicators and disease.RESULTS Comparison of mild and normal patients,patients with mild type had higher serum albumin(ALB)and CD8^+ levels(P<0.05),and there were no statistical differences in clinical symptoms and other laboratory indicators(P>0.05).Comparison of CT aggravated patients and non-aggravated ones:blood lymphocyte count(LYM),CD4^+,CD8^+ levels were lower in patients with aggravated CT(P<0.05),procalcitonin(PCT),and D-dimer level was significantly higher(P<0.05),and there was no statistical difference in high-sensitivity C-reactive protein(HPCRP)and C-reactive protein(CRP),but it was also higher in patients with aggravated CT.The age of the patient was also correlated with the increase in CT.The older the patient,the more likely CT was to aggravate(P<0.05).There was no statistical difference in clinical symptoms between the two groups(P>0.05).CONCLUSION The overseas imported cases are mainly mild.The older the patient is,the higher the PCT and D-dimer is,and the lower the LYM,ALB,CD4^+,and CD8^+ is,indicatirg the more serious the disease was and the possibility of progression to severe and critical type should be warned.The clinical symptoms and the severity of the disease are inconsistent,and cannot be used as indicators for evaluating the disease.

关 键 词：广州 新型冠状病毒肺炎 境外输入病例 临床特点 

分 类 号：R969[医药卫生—药理学]