金嗓开音胶囊联合头孢他美酯治疗急性咽炎的临床研究  

Clinical study on Jinsang Kaiyin Capsules combined with cefetame pivoxil in treatment of acute pharyngitis

作　　者：杨中元 时文杰[2] 张炜 YANG Zhong-yuan;SHI Wen-jie;ZHANG Wei(Department of ENT,Tianjin Ninghe District Hospital,Tianjin 301500,China;Department of ENT,Tianjin First Central Hospital,Tianjin 300192,China;Department of ENT,Cangzhou People's Hospital,Cangzhou 061001,China)

机构地区：[1]天津市宁河区医院耳鼻喉科,天津301500 [2]天津市第一中心医院耳鼻喉科,天津300192 [3]沧州市人民医院耳鼻喉科,河北沧州061001

出　　处：《现代药物与临床》2020年第7期1442-1445,共4页Drugs & Clinic

摘　　要：目的探讨金嗓开音胶囊联合头孢他美酯治疗急性咽炎的临床效果。方法选取2017年8月—2019年8月天津市宁河区医院收治的急性咽炎患者82例,随机分为对照组(41例)和治疗组(41例)。对照组患者口服盐酸头孢他美酯片,0.5 g/次,2次/d。治疗组在对照组治疗基础上口服金嗓开音胶囊,3粒/次,2次/d。两组患者均连续治疗7 d。观察两组患者临床疗效,同时比较治疗前后两组患者中医症状积分,及血清白细胞介素-1β(IL-1β)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)和IL-6水平。结果治疗后,对照组和治疗组临床有效率分别为75.61%和92.68%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组中医症状积分及血清IL-1β、hs-CRP、TNF-α和IL-6水平较治疗前均显著下降(P<0.05),且治疗组比对照组降低更明显(P<0.05)。结论金嗓开音胶囊联合头孢他美酯治疗急性咽炎疗效确切,不良反应低。Objective To explore the clinical effect of Jinsang Kaiyin Capsules combined with cefetame pivoxil in treatment of acute pharyngitis.Methods Patients(82 cases)with acute pharyngitis in Tianjin Ninghe District Hospital from August 2017 to August 2019 were randomly divided into control(41 cases)and treatment(41 cases)groups.Patients in the control group were po administered with Cefetame Pivoxil Hydrochloride Tablets,0.5 g/time,twice daily.Patients in the treatment group were po administered with Jinsang Kaiyin Capsules on the basis of the control group,3 grains/time,twice daily.Patients in two groups were treated for 7 d.After treatment,the clinical efficacy was evaluated,and the TCM symptom scores,and the serum level of IL-1β,hs-CRP,TNF-αand IL-6 in two groups before and after treatment were compared.Results After treatment,the clinical efficacy and in the control and treatment groups was 75.61%and 92.68%respectively,and there were differences between two groups(P<0.05).After treatment,the TCM symptom scores,and the serum level of IL-1β,hs-CRP,TNF-αand IL-6 in two groups were significantly decreased(P<0.05),and these indexes in the treatment group were significantly lower than those in the control group(P<0.05).Conclusion Jinsang Kaiyin Capsules combined with cefetame pivoxil in treatment of acute pharyngitis has definite curative effect and low adverse reaction.

关 键 词：金嗓开音胶囊 盐酸头孢他美酯片 急性咽炎 临床疗效 超敏C反应蛋白 肿瘤坏死因子-Α 

分 类 号：R988.2[医药卫生—药品]