麻杏石甘汤加味辅助治疗小儿耐药支原体肺炎风热犯肺证的临床疗效及对炎症因子的影响  

Clinical efficacy of modified Maxing Shigan Tang(麻杏石甘汤)in adjuvant treatment of drug-resistant mycoplasma pneumoniae pneumonia in children with wind-heat invading lung syndrome and its effects on inflammatory factors

作　　者：王佳红 何佳奇[1] 丁科[1] 陶倩 WANG Jiahong;HE Jiaqi;DING Ke;TAO Qian(TCM Dispensary,The First Hospital Affiliated to Zhejiang University of Chinese Medicine,Hangzhou,Zhejiang,310000,China;Chinese Materia Medica Department,Zhejiang Pharmaceutical College,Ningbo,Zhejiang,315100,China)

机构地区：[1]浙江中医药大学附属第一医院中药房,浙江杭州310000 [2]浙江医药高等专科学校中药学院,浙江宁波315100

出　　处：《中医儿科杂志》2020年第4期60-63,共4页Journal of Pediatrics of Traditional Chinese Medicine

基　　金：浙江省教育厅计划项目(Y201840577)。

摘　　要：目的观察麻杏石甘汤加味辅助治疗小儿耐药支原体肺炎风热犯肺证的临床疗效及对炎症因子的影响。方法选取2017年6月至2019年6月在浙江中医药大学附属第一医院儿科门诊就诊的60例耐药支原体肺炎风热犯肺证患儿,按随机数字表法分为对照组和治疗组,各30例。对照组在常规治疗的基础上口服阿奇霉素,治疗组在对照组治疗方法的基础上口服麻杏石甘汤加味。2组均7 d为1个疗程,连续治疗2个疗程后统计临床疗效、热退时间和咳嗽消失时间及炎症因子白细胞介素-6(IL-6)、白细胞介素-10(IL-10)及白细胞介素-17(IL-17)的含量变化。结果治疗组总有效率为93.3%(28/30),显著高于对照组的60.0%(18/30),2组比较,差异有统计学意义(P<0.05)。治疗组热退时间和咳嗽消失时间明显短于对照组,2组比较,差异均有统计学意义(P<0.05)。治疗前,2组血清IL-6、IL-10、IL-17水平比较,差异均无统计学意义(P>0.05),具有可比性。治疗后,2组血清IL-6、IL-17水平降低,IL-10水平升高,与同组治疗前比较,差异均有统计学意义(P<0.05),且治疗组下降/升高更显著(P<0.05)。结论麻杏石甘汤加味辅助治疗小儿耐药支原体肺炎风热犯肺证临床疗效满意,不仅缩短了病程,而且能显著改善炎症因子水平,值得临床推广应用。Objective To observe the clinical efficacy of modified Maxing Shigan Tang(麻杏石甘汤)in adjuvant treatment of macrolide-resistant mycoplasma pneumoniae pneumonia(MRMPP)in children with wind-heat invading lung syndrome and its effects on inflammatory factors.Methods From June 2017 to June 2019,60 cases of MRMPP with wind-heat invading lung syndrome consulted in outpatient pediatric service of The First Hospital Affiliated to Zhejiang University of Chinese Medicine were chosen and divided into control group and treatment group according to random number table method,with 30 cases in each.The control group was given oral azitromycin on the basis of routine treatment,while the treatment group was given oral modified Maxing Shigan Tang based on the therapeutic method of the control group.Seven days constituted 1 course of treatment for both groups.After consecutive treatment for 2 courses the clinical efficacy the time of abating fever,the disappearance time of cough and the level changes of inflammatory factors interleukin-6(IL-6),IL-10 and IL-17 of the 2 groups were counted.Results The total effective rate of the treatment group was 93.3%(28/30),which was significantly higher than 60.0%(18/30)of the control group,and the difference was statistically significant between the 2 groups(P<0.05).The time of abating fever and the disappearance time of cough in the treatment group were significantly shorter than those in the control group,and the difference was statistically significant between the 2 groups(P<0.05).Before treatment the difference was not statistically significant in serum levels of IL-6,IL-10 and IL-17 between the 2 groups(P>0.05),and they were comparable.After treatment,the serum levels of IL-6 and IL-17 in the 2 groups decreased,while the serum level of IL-10 increased,and the difference was statistically significant compared with the same group before treatment(P<0.05),moreover,the decrease/increase of the treatment group was more significant than those of the control group(P<0.05).Conclusion It has

关 键 词：支原体肺炎 小儿 风热犯肺证 麻杏石甘汤加味 临床观察 

分 类 号：R725.6[医药卫生—儿科]