冬虫夏草金水相生治疗肺脏疾病的作用及其生理基础  

Function of Jin-Shui Interaction Therapy on Lung Disease by Chinese Cordyceps and Its Physiological Basis

作　　者：马丽 李昌煜 钱正明 吴际 高建莉 MA Li;LI Changyu;QIAN Zhengming;WU Ji;GAO Jianli(Department of Basic Medicine of Zhejiang Chinese Medical University,Hangzhou 310053,Chi-na;Academy of Chinese Medical Sciences of Zhejiang Chinese Medical University,Hangzhou 310053,China;Key Laboratory of State Administration of Traditional Chinese Medicine,Sun Shine Lake Pharma Co.,LTD.,Dongguan 523850,China;Fourth Clinical Medical College of Zhejiang Chinese Medical University,Hangzhou 310053,China)

机构地区：[1]浙江中医药大学基础医学院,杭州310053 [2]中医药科学院,杭州310053 [3]广东东阳光药业有限公司国家中医药管理局重点研究室,东莞523850 [4]浙江中医药大学第四临床医学院,杭州310053

出　　处：《菌物研究》2020年第2期80-85,共6页Journal of Fungal Research

基　　金：浙江省自然科学基金项目(LY19H280010);浙江省重点实验室项目(2012E10002);国家自然科学基金项目(81473575)。

摘　　要：虫草及其衍生品保护肺、肾,具有抗肺癌、抗肺肾纤维化、保护肾功能、抗炎等作用,对支气管哮喘和肺癌辅助治疗的作用较好地体现了其补益肺肾的功效,而其对肺肾的共同作用暗合传统医学"金水相生"的理论。肺主气司呼吸、主行水,而肾主纳气、主水,对于机体的水液代谢共同发挥重要的作用。现代研究表明,肺和肾脏中与水液代谢相关的共同生理和病理学基础可能主要是水通道蛋白(aquaporins,AQPs)。AQPs在肺和肾脏中广泛存在,并参与调控二脏中水液分泌、吸收及细胞内外水的平衡。作为我国传统名贵中药,冬虫夏草具有补益肺肾、益精填髓等功效,而虫草及其相关产品在临床应用过程中体现出来的对肺肾相关疾病的共同调控效果,目前尚未有系统研究。文中基于金水相生理论,以水通道蛋白家族为生理学基础,就冬虫夏草对肺脏相关疾病的作用及机制进行综述,初步探索在金水相生理论指导下虫草通过对AQPs的调控,治疗肺部疾病的临床应用和科学内涵。Cordyceps and cordycipitoid fungi protect lung and kidney including anti-lung cancer,anti-pulmonary and renal fibrosis,protect renal function,anti-inflammatory. The effect of the adjuvant treatment of bronchial asthma and lung cancer better reflects the traditional medical theory of Jin-Shui interaction. Modern research shows that aquaporins( AQPs) may be the common physiological and pathological basis of water metabolism in the lung and kidney. AQPs which were widely found in the lung and kidney,play an important role in regulating the secretion and absorption of water and the balance of water inside and outside the cells. Chinese cordyceps is a traditional Chinese medicine beneficial to lung and kidney,and replenish spirit. However,there is no systematic study on the joint regulatory effect of Chinese cordyceps and cordycipitoid fungi on the lung and kidney related diseases in the clinical application. Based on the theory of Jin-Shui interaction,this paper reviews the effects and mechanisms of Chinese cordyceps and cordycipitoid fungi on lung-related diseases,and explores the clinical application and scientific connotation under the guidance of the understanding of Chinese cordyceps and cordycipitoid fungi.

关 键 词：冬虫夏草 金水相生 慢性阻塞性肺疾病 支气管哮喘 肺癌 水通道蛋白 

分 类 号：S567.35[农业科学—中草药栽培] Q949.95[农业科学—作物学]