结状神经节神经元离子通道和受体参与血压调节的研究进展  

Research progress on ion channels and receptors in nodose ganglion neurons involved in blood pressure regulation

作　　者：霍立芳 贾占峰[2] 张炜 HUO Li-fang;JIA Zhan-feng;ZHANG Wei(Institute of Chinese Integrative Medicine,Hebei Medical University,Shijiazhuang 050017,China;The Key Laboratory of New Drug Pharmacology and Toxicology,Hebei Medical University,Shijiazhuang 050017,China)

机构地区：[1]河北医科大学中西医结合研究所,河北石家庄050017 [2]河北医科大学,新药药理和毒理重点实验室,河北石家庄050017

出　　处：《药学学报》2020年第7期1364-1372,共9页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(81872848);科技部重大新药创制项目(2018ZX09711001-004-003);京津冀基础研究项目(H2018206641);河北省三三三人才项目(A201701010068)。

摘　　要：高血压是心血管疾病中最常见的疾病,近年来研究发现,压力感受器传入活动减少可能是高血压最主要的诱发因素。压力感受器初级传入神经的胞体位于结状神经节(nodose ganglion,NG),NG中的离子通道和受体会影响压力感受器敏感性以及神经元的兴奋性进而影响血压调节。本文重点就NG神经元中的离子通道、受体和其他蛋白分子通过调节压力感受器反射敏感性进而影响血压的研究进展进行综述。Hypertension is the most common cardiovascular disease.In recent years,reduced baroreceptor activity has been suggested as a main cause of hypertension.The cell body of the primary afferent nerve of the baroreceptor is located in the nodose ganglion(NG).The ion channels and receptors in the NG can affect baroreceptor sensitivity and neuronal excitability,thus regulating blood pressure.This review focuses on recent research progress on ion channels,receptors and other proteins in NG neurons that are involved in modulating the sensitivity of the baroreceptor reflex to regulate blood pressure.

关 键 词：结状神经节 离子通道 受体 压力感受器反射 高血压 

分 类 号：R966[医药卫生—药理学]