雪莲的化学成分及药理作用研究进展  

Research advances on the chemical constituents and pharmacological effects of snow lotus

作　　者：杨璐铭 陈虎彪[2] 郭乔如 波拉提·马卡比力 周雯敏 黄佩敏 吴增宝[4] 张建业 YANG Lu-ming;CHEN Hu-biao;GUO Qiao-ru;Makabili Bolati;ZHOU Wen-min;HUANG Pei-min;WU Zeng-bao;ZHANG Jian-ye(Guangdong Provincial Key Laboratory of Molecular Target and Clinical Pharmacology,School of Pharmaceutical Sciences,Guangzhou Medical University,Guangzhou 511436,China;School of Chinese Medicine,Hong Kong Baptist University,Hong Kong,China;Xinjiang Institute of Materia Medica,Urumqi 830004,China;Key Laboratory of Xinjiang Phytomedicine Resources of Ministry of Education,School of Pharmacy,Shihezi University,Shihezi 832000,China)

机构地区：[1]广州医科大学药学院,广东省分子靶标与临床药理学重点实验室,广东广州511436 [2]香港浸会大学中医药学院,香港特别行政区 [3]新疆维吾尔自治区药物研究所,新疆乌鲁木齐830004 [4]石河子大学药学院,新疆特种植物药资源省部共建教育部重点实验室,新疆石河子832000

出　　处：《药学学报》2020年第7期1466-1477,共12页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(U1903126,81773888)。

摘　　要：雪莲是一种具有广泛药理活性的药用植物,传统医学将其用于治疗风湿性关节炎、感冒咳嗽、痛经以及高原反应。本文将对天山雪莲(Saussurea involucrata,SI)、苞叶雪莲(Saussurea obvallata,SO)、绵头雪兔子(Saussurea laniceps,SL)、水母雪兔子(Saussurea medusa,SM)、星状雪兔子(Saussurea stella,SS)和三指雪兔子(Saussurea tridactyla,ST)的黄酮类、木脂素类、酚醛类、苯丙素类和倍半萜类化合物等多种活性成分进行整理,并对其抗肿瘤、抗炎、抗氧化、促进脂质代谢的药理作用及其相关分子机制进行综述,为将来雪莲的中药化学的研究和药理活性的研究提供参考。Snow lotus is a medicinal plant with a wide range of pharmacological activities.It has been used to treat rheumatoid arthritis,cough with cold,stomach ache,dysmenorrhea,and altitude sickness in traditional medicine.This review summarizes the bioactive components in six species of snow lotus including flavonoids,lignans,phenolic compounds,phenylpropanoids,and sesquiterpenes present in Saussurea involucrate(SI),Saussurea obvallata(SO),Saussurea laniceps(SL),Saussurea medusa(SM),Saussurea stella(SS)and Saussurea tridactyla(ST).We review the pharmacological and related molecular mechanisms by which these components exert antineoplastic,anti-inflammatory,and antioxidant effects and promote lipid catabolism,and provide a reference for the future study of the traditional Chinese medicinal chemistry and pharmacological activities of snow lotus.

关 键 词：雪莲 黄酮 木脂素 抗肿瘤 抗炎 

分 类 号：R284[医药卫生—中药学]