中国南海柳珊瑚Junceella fragilis中一个新的briarane型二萜  

A new briarane-type diterpenoid from the South China Sea gorgonian Junceella fragilis

作　　者：沈寿茂 郭跃伟 李序文 SHEN Shou-mao;GUO Yue-wei;LI Xu-wen(State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;School of Chinese Materia Medica,Nanjing University of Chinese Medicine,Nanjing 210023,China)

机构地区：[1]中国科学院上海药物研究所,新药研究国家重点实验室,上海201203 [2]南京中医药大学新中药学院,江苏南京210023

出　　处：《药学学报》2020年第7期1661-1665,共5页Acta Pharmaceutica Sinica

基　　金：科技部“重大新药创制”重大专项(2018ZX09711-001-001-009);中国科学院青年创新促进会会员项目(2016258)。

摘　　要：综合利用硅胶、凝胶柱色谱及半制备HPLC等分离技术,对中国南海西瑁岛的脆灯芯柳珊瑚Junceella fragilis Ridley的丙酮提取物进行化学成分的研究,共分离得到6个化合物。根据其理化性质和各种波谱数据分析,分别鉴定为:fragilide Y(1)、fragilide D(2)、胆甾醇(3)、过氧化麦角甾醇(4)、2’-脱氧胸腺嘧啶核苷(5)和cis-thyminenol(6)。其中化合物1为新的briarane型二萜;生物活性结果表明,化合物1~6均未表现明显的抗炎及肿瘤细胞毒性作用。The chemical constituents of gorgonian Junceella fragilis Ridley,collected from Ximao Island,the South China Sea,were investigated.A new briarane-type diterpenoid,named fragilide Y(1),together with five known compounds(2–6),namely fragilide D(2),cholesterol(3),ergosterol peroxide(4),2’-deoxythymidine(5)and cis-thyminenol(6),were isolated from the acetone extract of J.fragilis.The structure of the new compound 1 was elucidated by extensive spectroscopic analysis,while the known compounds were identified by comparison with the reported data.In bioassay,none of these compounds displayed obvious anti-inflammatory and cytotoxic effects.

关 键 词：柳珊瑚 Junceella fragilis briarane型二萜 中国南海 

分 类 号：R284[医药卫生—中药学]