单中心上尿路结石患者血生化代谢危险因素分析  

Analysis of blood biochemical metabolic risk factors in patients with upper urinary calculi in a single center

作　　者：张小马 张震 程宗三[1] 古宏兵[1] 林长明 梁朝朝[2] Xiao-ma Zhang;Zhen Zhang;Zong-san Cheng;Hong-bing Gu;Chang-ming Lin;Chao-zhao Liang(Department of Urology,The Fourth Affiliated Hospital of AnHui Medical University,Hefei,Anhui 230012,China;Department of Urology,The First Affiliated Hospital of AnHui Medical University,Hefei,Anhui 230022,China)

机构地区：[1]安徽医科大学第四附属医院泌尿外科,安徽合肥230012 [2]安徽医科大学第一附属医院泌尿外科,安徽合肥230022

出　　处：《中国现代医学杂志》2020年第15期65-69,共5页China Journal of Modern Medicine

摘　　要：目的分析单中心上尿路结石患者的血生化代谢水平,探索上尿路结石形成的代谢危险因素。方法回顾性分析2017年2月—2018年2月安徽医科大学第四附属医院随机抽取的单中心上尿路结石组和非结石组患者的临床资料,比较两组患者的血生化代谢指标水平。结果按照纳入和排除标准,结石组患者144例,年龄21~85岁,平均(52.67±13.42)岁。非结石组76例,年龄15~86岁,平均(56.89±18.02)岁。结石组甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、血肌酐、血尿酸水平高于非结石组(P<0.05),高密度脂蛋白胆固醇(HDL-C)、肾小球滤过率(GFR)水平低于非结石组(P<0.05)。多因素Logistic分析显示低HDL-C(OlR=3.747,95%CI:1.865,7.529)、血肌酐(OlR=1.028,95%CI:1.013,1.044)或降低的GFR(OlR=0.962,95%CI:0.944,0.980)是上尿路结石的代谢危险因素(P?<0.05)。结论低HDL-C、血肌酐是上尿路结石形成共同的代谢危险因素,降低的GFR是上尿路结石的危险因素。Objective To analyze the levels of blood biochemical metabolites of patients with upper urinary calculi,and to explore the metabolic risk factors for the formation of upper urinary calculi in a single center.Methods From February 2017 to February 2018,the medical records of patients with upper urinary calculi and non-stone who were randomly selected were analyzed retrospectively,and the levels of blood biochemical metabolites were compared between the two groups.Results According to the criteria of inclusion and exclusion,144 patients were enrolled in the stone group with an average age of (52.67±13.42) years (range 21 to 85 years).There were 76 patients in non-stone group,with an average age of (56.89±18.02) years (ranged from 15 to 86 years).The levels of serum triglyceride (TG),serum low density lipoprotein cholesterol (LDL-C),serum creatinine and uric acid in stone group were higher than those in non-stone group (P<0.05).The levels of estimated glomerular filtration rate (GFR) and high density lipoprotein cholesterol (HDL-C) in stone group were lower than those in non-stone group (P<0.05).Multivariate logistic regression analysis showed that low-HDL-C (OlR=3.747,95% CI:1.865,7.529),serum creatinine (OlR=1.028,95% CI:1.013,1.044) or decreased GFR (OlR=0.962,95% CI:0.944,0.980) were metabolic risk factors for upper urinary calculi (P<0.05).Conclusion Low HDL-C and serum creatinine are common metabolic risk factors for the formation of upper urinary calculi,and decreasing GFR is a risk factor of upper urinary calculi.

关 键 词：尿路结石 代谢异常 脂蛋白类 危险因素 

分 类 号：R692.4[医药卫生—泌尿科学]