利胆排石浓煎剂对保胆取石术后胆囊收缩率及血浆胆囊收缩素的影响  

Effect of Lidanpaishi Decoction on Gallbladder Contraction Rate and Plasma Cholecystokinin after Gallbladder-preserving Cholecystolithotomy

作　　者：张稳 王小俊 缪雪华[1] 刘文生[1] ZHANG Wen;WANG Xiao-jun;MIAO Xue-hua(Department of General Surgery,Nanjing Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Nanjing University of Traditional Chinese Medicine,Nanjing(210014),China)

机构地区：[1]南京中医药大学附属南京市中西医结合医院普通外科,南京210014

出　　处：《中国中西医结合外科杂志》2020年第4期671-674,共4页Chinese Journal of Surgery of Integrated Traditional and Western Medicine

基　　金：南京市医学科技发展项目(YKK16209)。

摘　　要：目的:观察利胆排石浓煎剂对保胆取石术后胆囊收缩率及血浆胆囊收缩素(CCK)的影响。方法:选取在我科行双镜联合保胆取石术的患者118例,随机数字法分为观察组及对照组,每组59例。两组患者在同种饮食护理指导下,观察组术后口服利胆排石浓煎剂,对照组不服用利胆排石浓煎剂。分别于术后1、3、6月用酶联免疫法测定血浆CCK水平,并用B超检查计算胆囊收缩率,统计口服中药过程中不良反应及结石复发情况。结果:两组患者均未出现结石复发,观察组患者口服中药过程中均未出现不良反应。两组患者术后1、3、6月的CCK水平均高于术前(P<0.05),同期比较,观察组的CCK水平较对照组均显着升高(P<0.05)。观察组术后1、3、6月的胆囊收缩率高于术前,对照组术后3、6月的胆囊收缩率高于术前(P<0.05),同期比较,观察组术后3、6月的胆囊收缩率高于对照组(P<0.05)。结论:保胆取石术后口服利胆排石浓煎剂可望提高CCK水平及胆囊收缩率,增强胆囊收缩功能,对术后胆囊结石的复发有一定的预防作用。Objective To observe the effect of Lidanpaishi decoction on gallbladder contraction rate and plasma cholecystokinin(CCK)after cholecystolithotomy.Methods 118 patients undergoing gallstonepreserving operation were selected as the research objects.They were randomly divided into observation group and control group.Under the guidance of the same dietary nursing,the observation group was given Lidanpaishi decoction after operation,while the control group was not.One month,three months and half a year after operation,the CCK in plasma was measured by ELISA,and the gallbladder contraction rate was calculated by B-mode ultrasonography.The adverse reactions and the recurrence of stones in the course of oral administration of traditional Chinese medicine were counted.Results No stone recurrence occurred in both groups and no adverse reactions occurred in the course of oral administration of traditional Chinese medicine in the observation group.The levels of CCK in one month,three months and six months after operation in the two groups were higher than those before operation(P<0.05).Compared with the control group at the same period,the levels of CCK in the observation group were significantly higher(P<0.05).The contraction rate of gallbladder in the observation group was higher than that before operation in one month,three months and six months after operation(P<0.05),while that in the control group was higher than that before operation in three months and six months after operation(P<0.05).Contemporary comparison,the contraction rate of gallbladder in the observation group was higher than that in the control group in three months and six months after operation(P<0.05).Conclusion Oral Lidanpaishi decoction may effectively improve CCK level and gallbladder contraction rate,enhance gallbladder contraction function and prevent the recurrence of gallbladder stones after cholecystolithotomy.

关 键 词：胆囊收缩素 胆囊结石 保胆取石术 利胆排石浓煎剂 

分 类 号：R657.4[医药卫生—外科学]