血浆内皮素-1和血小板p-选择素在慢性阻塞性肺疾病中的检测及临床意义  

Detection and clinical significance of plasma endothelin-1 and platelet p-selectin in chronic obstructive pulmonary disease

作　　者：王志刚 郑红艳 林学军 WANG Zhi-gang;ZHENG Hong-yan;LIN Xue-jun(Department of Respiratory Medicine,People′s Hospital Affiliated to Quanzhou Medical College,Fujian Province,Quanzhou362000,China)

机构地区：[1]泉州医学高等专科学校附属人民医院呼吸内科,福建泉州362000

出　　处：《中国当代医药》2020年第22期4-7,共4页China Modern Medicine

基　　金：2015年福建省泉州市卫生计生科研资助项目(16)。

摘　　要：目的探讨血浆内皮素-1(ET-1)和血小板p-选择素(CD62P)在慢性阻塞性肺疾病(COPD)患者中的水平及临床意义。方法选取2017年6月~2018年9月我院呼吸内科收治的68例COPD急性发作期(AECOPD)患者作为A组,另外选取同期门诊复查的79例COPD稳定期患者作为B组;选取同期体检中心的72例健康体检者作为健康对照C组。分别检测和比较三组的血浆ET-1和血小板表面CD62P水平,并分析A、B两组的血浆ET-1和血小板表面CD62P水平与动脉血氧分压(PaO_2)和动脉血二氧化碳分压(PaCO_2)的关系。结果 A组的血浆ET-1和血小板CD62P水平均高于B组和C组,差异有统计学意义(P<0.05);B组和C组的血浆ET-1和血小板CD62P水平比较,差异无统计学意义(P>0.05)。A组与B组的PaO_2、PaCO_2比较,差异无统计学意义(P>0.05)。血浆ET-1、血小板CD62P水平与PaO_2成负相关(r=-0.41、-0.43,P<0.05),与PaCO_2成正相关(r=0.56、0.58,P<0.05)。结论检测COPD患者体内的ET-1和CD62P含量,有助于COPD患者可能存在血栓前状态(PTS)的早期发现和临床干预治疗。Objective To investigate the level and clinical significance of plasma endothelin-1(ET-1)and platelet p-selectin(CD62P)in patients with chronic obstructive pulmonary disease(COPD).Methods A total of 68 patients with acute exacerbation of COPD(AECOPD)in our hospital from June 2017 to September 2018 were selected as group A,79 patients with stable COPD who were reviewed in the same clinic were selected as the group B,and a total of 72 healthy examinees served as the healthy control group C.The plasma ET-1 and platelet surface CD62P levels of the three groups were detected and compared,and the relationship between the plasma ET-1,platelet surface CD62P levels and arterial blood oxygen partial pressure(PaO2),arterial blood carbon dioxide partial pressure(PaCO2)was analyzed in group A and B.Results The plasma ET-1 and platelet CD62P levels in group A were higher than those in group B and C,and the differences were statistically significant(P<0.05).There were no significant differences in the levels of plasma ET-1 and platelet CD62P between group B and group C(P>0.05).There were no significant differences in PaO2 and PaCO2 between group A and group B(P>0.05).Plasma ET-1 and platelet CD62P levels were negatively correlated with PaO2(r=-0.41,-0.43,P<0.05),and positively correlated with PaCO2(r=0.56,0.58,P<0.05).Conclusion The detection of ET-1 and CD62P in COPD patients is helpful for the early detection and clinical intervention of prethrombotic state(PTS)in COPD patients.

关 键 词：慢性阻塞性肺疾病 内皮素-1 P-选择素 血栓前状态 

分 类 号：R563.5[医药卫生—呼吸系统]