低剂量米力农治疗≥80岁慢性心力衰竭患者的效果  

Effect of low-dose Milrinone in the treatment of chronic heart failure patients over 80 years old

作　　者：唐爱 杨贵志 TANG Ai;YANG Gui-zhi(Department of Ultrasonography,Ji′nan Hospital of Integrated Traditional Chinese and Western Medicine,Shandong Province,Ji′nan271100,China;Department of Geriatrics,Ji′nan Hospital of Integrated Traditional Chinese and Western Medicine,Shandong Province,Ji′nan271100,China)

机构地区：[1]山东省济南市中西医结合医院超声科,山东济南271100 [2]山东省济南市中西医结合医院老年病科,山东济南271100

出　　处：《中国当代医药》2020年第22期69-72,共4页China Modern Medicine

摘　　要：目的观察低剂量米力农治疗≥80岁慢性心力衰竭(CHF)患者的效果。方法选取2018年10月~2019年10月我院收治的60例≥80岁CHF患者,依据随机数字表法分为治疗组和对照组,各30例。治疗组采用标准治疗+低剂量米力农,对照组采用标准治疗。比较两组的治疗总有效率、血压、心率、左室射血分数(LVEF)值、左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、左室收缩末期容积(LVESV)、左室舒张末期容积(LVEDV)和6 min步行试验距离。结果治疗组的总有效率为86.7%,显著高于对照组的53.3%,差异有统计学意义(P<0.01)。治疗组的LVEF[(57.2±9.3)%]、6 min步行试验距离[(499.5±50.2)m]明显高于对照组[(45.7±8.8)%、(392.5±90.8)m],差异有统计学意义(P<0.01)。治疗组的LVESV[(116.3±52.7)ml]、LVEDV[(192.6±45.4)ml]、LVESD[(47.4±6.3)mm]低于对照组[(126.2±41.5)ml、(201.9±50.2)ml、(50.2±8.6)mm],差异有统计学意义(P<0.05)。治疗组的LVEDD为(60.6±10.1)mm,与对照组的(61.2±10.8)mm比较,差异无统计学意义(P>0.05)。治疗组治疗后的LVEF[(57.2±9.3)%]、6 min步行试验距离[(499.5±50.2)m]显著高于治疗前[(37.3±11.4)%、(246.6±72.2)m],差异有统计学意义(P<0.01)。治疗组治疗后的LVESV、LVEDV、LVEDD、LVESD低于治疗前,差异有统计学意义(P<0.05);对照组治疗后的LVEF、6 min步行试验距离高于治疗前,差异有统计学意义(P<0.05)。对照组治疗前后的LVESV、LVEDV、LVESD、LVEDD比较,差异均无统计学意义(P>0.05)。两组患者治疗前后的血压、心率比较,差异无统计学意义(P>0.05)。结论低剂量米力农能明显改善≥80岁CHF患者的心功能及运动耐量。Objective To observe the effect of low-dose Milrinone in the treatment of chronic heart failure(CHF)patients over 80 years old.Methods A total of 60 patients over 80 years old with CHF were selected and divided into the treatment group and the control group by random number table method,30 cases in each group.The treatment group was treated with standard treatment combined with low-dose Milrinone,and the control group was treated with standard treatment.The total effective rate,blood pressure,heart rate,left ventricular ejection fraction(LVEF),left ventricular end diastolic diameter(LVEDD),left ventricular end systolic diameter(LVESD),left ventricular end systolic volume(LVESV),left ventricular end diastolic volume(LVEDV)and 6-minute walking test distance were compared between the two groups.Results The total effective rate was 86.7%in the treatment group,which was significantly higher than that in the control group(53.3%),the difference was statistically significant(P<0.01).The LVEF([57.2±9.3]%)and 6-minute walking test distance[(499.5±50.2)m]in the treatment group were higher than those in the control group([45.7±8.8]%and[392.5±90.8]m),the differences were statistically significant(P<0.01).The LVESV([116.3±52.7]ml),LVEDV([192.6±45.4]ml)and LVESD([47.4±6.3]mm)in the treatment group were lower than those in the control group([126.2±41.5]ml,[201.9±50.2]ml and[50.2±8.6]mm),with statistical significances(P<0.05).The LVEDD in the treatment group was(60.6±10.1)mm,which in the control group was(61.2±10.8)mm,with no statistical significance(P>0.05).The LVEF([57.2±9.3]%),6-minute walking test distance([499.5±50.2]m)in the treatment group after treatment were higher than those before treatment([37.3±11.4]%,[246.6±72.2]m),the differences were statistically signifi cant(P<0.01).The LVESD,LVEDD,LVEDV and LVESV in the treatment group after treatment were lower than those before treatment,the differences were statistically significant(P<0.05).The LVEF and 6-minute walking test distance of the control group afte

关 键 词：慢性心力衰竭 米力农 高龄 6 min步行试验 超声检查 临床疗效 

分 类 号：R541.6[医药卫生—心血管疾病]