心肌胰岛素抵抗及其发生机制的研究进展  

Advances in the molecular mechanism of myocardial insulin resistance

作　　者：陈开远 梁贵友 Chen Kaiyuan;Liang Guiyou(Department of Cardiothoracic Surgery,Affiliated Hospital of Guizhou Medical University,Guiyang 550000,China)

机构地区：[1]贵州医科大学附属医院心血管外科,贵阳550000

出　　处：《中华胸心血管外科杂志》2020年第7期442-446,共5页Chinese Journal of Thoracic and Cardiovascular Surgery

基　　金：国家自然科学基金(81560058,81960051);贵州省科技支撑计划(黔科合支撑[2017]2969);贵州省高层次创新型人才培养(黔科合平台人才[2016]4034号)。

摘　　要：心肌缺血-再灌注损伤是体外循环术后心功能障碍甚至死亡的主要原因,其发生机制复杂且牵涉广泛。最近的研究发现,心肌胰岛素抵抗是心肌缺血-再灌注损伤发生的重要机制,但其具体机制尚未完全阐明。本文总结心肌胰岛素抵抗与心肌缺血-再灌注损伤相关作用机制研究,以期初步阐明心肌胰岛素抵抗在心肌缺血-再灌注损伤中的调控机制,为心肌缺血-再灌注损伤的防治研究提供新思路。Myocardial ischamic-reperfusion(MIRI)is one of the leading causes of cardiac dysfunction and even death with patient after cardiopulmonary bypass,its mechanism is complex and involved widely.Recent research has found that myocardial insulin resistance is an important mechanism of MIRI.But its mechanism has not been fully elucidated.Therefore,this paper reviews the study of myocardial insulin resistance and myocardial ischemia-reperfusion injury mechanism in recent years,to preliminarily clarify the regulatory role of insulin signal in MIRI and provide new ideas for the future research on the prevention and treatment of MIRI.

关 键 词：心功能障碍 心肌胰岛素抵抗 体外循环术后 相关作用机制 心肌缺血-再灌注损伤 防治研究 调控机制 研究进展 

分 类 号：R654.2[医药卫生—外科学]