不同孔结构介孔二氧化硅纳米粒对艾塞那肽的载药性能比较  

Exenatide on Mesoporous Silica Nanoparticles with Different Pore Structure:A Comparative Study

作　　者：陈翠微 余丽华 王建超 王增 CHEN Cui-wei;YU Li-hua;WANG Jian-chao;WANG Zeng(Institute of Cancer Research and Basic Medical Sciences of Chinese Academy of Sciences,Cancer Hospital of University of Chinese Academy of Sciences,Zhejiang Cancer Hospital,Dept.of Pharmacy,Hangzhou 310022,China)

机构地区：[1]中国科学院肿瘤与基础医学研究所,中国科学院大学附属肿瘤医院,浙江省肿瘤医院药剂科,浙江杭州310022

出　　处：《海峡药学》2020年第7期4-9,共6页Strait Pharmaceutical Journal

摘　　要：目的考察SBA-15、MCM-41这两种型号的介孔二氧化硅载体载艾塞那肽的处方工艺以及比较两者载药性能差异和体外释药特性。方法采用单因素考察结合正交试验,以两种载体载艾塞那肽的载药量为评价指标,进行处方工艺的优化,采用透析袋法测定两种载药纳米粒的体外释药特性。结果 SBA-15载艾塞那肽的优化处方为温度50℃、TEOS用量10mL、P-123的用量3mL,测得平均载药量为14.93%;MCM-41载艾塞那肽的优化处方为温度80℃、CTAB浓度0.3%、TEOS的用量1.7mL,测得平均载药量为14.63%,两种载药纳米粒均呈现明显的缓释特性。结论相比于MCM-41载体,SBA-15载体具有相对大的载药量,且稳定性良好。OBJECTIVE To investigate the preparation process of two kinds of mesoporous silica nanoparticles MCM-41 and SBA-15 to load exenatide(EXT).The drug loading abilities andin vitro drug release characteristics of the two kinds of carries were compared.METHODS The study was carried out with single factor investigation and orthogonal experiment and the drug loading efficiencywas used as the index of inclusion process.The in vitro drug release characteristics were investigated by dialysis bag method.RESULTS The optimal conditions of EXT loaded SBA-15 were:temperature:50℃,TEOS:9 mL,P-123:3 mL,the average drug loading efficiency was 14.93%;the optimal conditions of EXT loaded MCM-41 were:temperature:80℃,CTAB:0.3%,TEOS:1.7 mL,the average drug loading efficiency was 14.63%.CONCLUSION SBA-15 is more feasible to load EXT than MCM-41.

关 键 词：艾塞那肽 SBA-15介孔二氧化硅 MCM-41介孔二氧化硅 载药量 

分 类 号：R94[医药卫生—药剂学]