槲皮素缓释片的制备及质量评价研究  

Preparation and Quality Evaluation of Quercetin Sustained Release Tablets

作　　者：缪怡烨 吉冬洋 喻樊[1,2,3] MIAO Yi-ye;JI Dong-yang;YU Fan(College of Pharmacy,Yancheng Teachers University,Yancheng 224051,China;Jiangsu Provincial Key Laboratory of Coastal Wetland Bioresources and Environmental Protection,Yancheng 224002,China;Nanjing University of Technology,Nanjing 210000,China)

机构地区：[1]药学院盐城师范学院,江苏盐城224051 [2]江苏省滩涂生物资源与环境保护重点建设实验室,江苏盐城224002 [3]南京工业大学,江苏南京210000

出　　处：《海峡药学》2020年第7期9-12,共4页Strait Pharmaceutical Journal

基　　金：江苏省自然科学基金面上项目(编号:BK20181478)。

摘　　要：目的以HPMC为亲水凝胶骨架,以可溶性淀粉、交联CMC-Na、滑石粉为辅料自制规格为0.25g/片的槲皮素缓释片,以达到减少用药量、用药次数以及节约成本的目的。方法以HPMC K4M、可溶性淀粉、交联CMC-Na、滑石粉为辅料,采用压片法制备槲皮素缓释片,利用硬度计测定硬度,根据药典测定释放度的方法测定释放度。结果自制槲皮素缓释片的配方是槲皮素74%、HPMC为2%、可溶性淀粉为20%、交联CMC-Na3.5%、滑石粉0.5%。结论自制的槲皮素缓释片基本符合缓释要求,达到缓释效果。OBJECTIVE HPMC is the Hydrophilic gel matrix.Starch,crosslinked CMC-Na,talcum powder were used as auxiliary to make homemade specifications for 0.25 g quercetin sustained release tablets,in order to reduce the dosage,delivery times and save the cost.METHODS HPMC K4 M,soluble starch,crosslinked CMC-Na,talcum powder were used as auxiliary,wet granulation method was adopted to prepare quercetin sustained release tablets,hardness tester was used to determination of hardness,the dissolution of quercetin sustained release tablets was determined according to the pharmacopoeia.RESULTS Quercetin sustained release tablets formulation include 74% quercetin,2% HPMC,20% soluble starch,3.5% crosslinked CMC-Na,0.5% talcum powder.CONCLUSION The quercetin sustained release tablets prepared by ourselves were qualified.The sustained release effect was achieved.

关 键 词：槲皮素 缓释片 溶出度 

分 类 号：R94[医药卫生—药剂学]