磷酸肌酸钠联合左卡尼汀注射液治疗新生儿缺氧缺血性脑病的临床研究  

Clinical trial of sodium creatine phosphate combined with L-carnitine injection in the treatment of neonatal hypoxic ischemic encephalopathy

作　　者：陈静[1] 宋波[2] 朱颖[1] CHEN Jing;SONG Bo;ZHU Ying(Department of Pediatrics,Second Affiliated Hospital of Qiqihar Medical College,Qiqihar 161006,Heilongjiang Province,China;Department of Clinical Pathogens,Qiqihar Medical College,Qiqihar 161006,Heilongjiang Province,China)

机构地区：[1]齐齐哈尔医学院附属第二医院儿科,黑龙江齐齐哈尔161006 [2]齐齐哈尔医学院临床病原教研室,黑龙江齐齐哈尔161006

出　　处：《中国临床药理学杂志》2020年第14期1938-1941,共4页The Chinese Journal of Clinical Pharmacology

摘　　要：目的观察磷酸肌酸钠联合左卡尼汀注射液对新生儿缺氧缺血性脑病(HIE)影响。方法将68例HIE患儿随机数字表法分为对照组(30例)和试验组(38例)。对照组给予磷酸肌酸钠0.5 g,加入5%葡萄糖溶液20 mL,每天1次,静脉滴注;试验组在对照组的基础上给予0.05 g·kg-1左卡尼汀注射液,加入0.9%氯化钠注射液20 mL每天1次,静脉滴注。2组均连续治疗14 d。用新生儿神经行为(NABA)评分比较2组患儿的临床疗效;用酶联免疫吸附法检测患儿治疗前后血清脂联素(APN)、白细胞介素-6(IL-6)、低氧诱导因子-1α(HIF-1α)、白细胞介素-1β(IL-1β)、内皮素-1(ET-1)的水平。结果治疗后,对照组和试验组的临床总有效率为76.6%,92.1%,差异有统计学意义(P<0.05)。治疗后,对照组及试验组患儿血清脂联素水平分别为(32.17±4.69),(39.87±5.62)mg·L^-1,白细胞介素-6分别为(45.14±5.62),(28.13±4.17)ng·L^-1,低氧诱导因子-1α分别为(0.61±0.13),(0.39±0.08)ng·mL^-1,白细胞介素-1β分别为(34.13±6.19),(26.17±4.54)ng·L^-1,内皮素-1水平分别为(55.21±6.74),(46.23±5.24)pg·mL^-1,差异均有统计学意义(均P<0.05)。结论磷酸肌酸钠联合左卡尼汀注射液对新生儿缺氧缺血性脑病的疗效显著。Objective To observe the effect of sodium creatine phosphate combined with L-carnitine injection in the treatment of neonatal hypoxic ischemic encephalopathy(HIE).Methods Sixty-eight children with HIE were randomly divided into control group(30 cases)and treatment group(38 cases).Control group was given sodium creatine phosphate 0.5 g,added to 5%glucose solution 20 mL,once a day,intravenous infusion.Treatment group was given 0.05 g·kg^-1 L-carnitine injection,added to 0.9%NaCl 20 mL,once a day,intravenous infusion,on the basis of control group.Both groups were treated for 14 d.The clinical effects of the two groups were compared by neonatal neurobehavioral(NABA)scores.Enzyme-linked immunosorbent assay was used to observe the serum adiponectin(APN),interleukin-6(IL-6),hypoxia-inducible factor-1α(HIF-1α),interleukin-1β(IL-1β),endothelin-1(ET-1)before and after treatment in two groups.Results After treatment,the total effective rates of control group and treatment were 76.6%,92.1%,with significant difference(P<0.05).After treatment,serum adiponectin levels in control group and treatment group were(32.17±4.69)and(39.87±5.62)mg·L^-1,serum interleukin-6 levels were(45.14±5.62),(28.13±4.17)ng·L^-1,hypoxia-inducible factor-1αwere(0.61±0.13),(0.39±0.08)ng·mL^-1,and interleukin-1βwere(34.13±6.19),(26.17±4.54)ng·L^-1,endothelin-1 levels were(55.21±6.74)and(46.23±5.24)pg·mL^-1,all with significant difference(all P<0.05).Conclusion Sodium creatine phosphate combined with L-carnitine injection has a significant effect on neonatal hypoxic ischemic encephalopathy.

关 键 词：磷酸肌酸钠 新生儿缺氧缺血性脑病 左卡尼汀注射液 新生儿神经行为评分 

分 类 号：R97[医药卫生—药品]