比索洛尔/氢氯噻嗪复合剂与缬沙坦在原发性高血压患者降压效果的比较研究  

Comparison of bisoprolol/hydrochlorothiazide and valsartan in the treatment of essential hypertension

作　　者：曾位位 郭惠娟[1] 钟国平[3] ZENG Wei-wei;GUO Hui-juan;ZHONG Guo-ping(Department of Pharmacy,Bao’an Maternal and Child Health Hospital,Shenzhen 518102,Guangdong Province,China;Department of Medicine and Therapeutics,Prince of Wales Hospital,The Chinese University of Hong Kong,Hong Kong 999077,China;School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510080,Guangdong Province,China)

机构地区：[1]深圳市宝安区妇幼保健院药剂科,广东深圳518102 [2]香港中文大学威尔斯亲王医院内科与药物治疗学系,中国香港999077 [3]中山大学药学院,广东广州510080

出　　处：《中国临床药理学杂志》2020年第14期1946-1948,1956,共4页The Chinese Journal of Clinical Pharmacology

基　　金：深圳市宝安区医疗卫生基础研究基金资助项目(2019JD353)。

摘　　要：目的比较比索洛尔/氢氯噻嗪复合剂(Bisoprolol/HCTZ)与缬沙坦治疗原发性高血压病的临床疗效和耐受性。方法将44例原发性高血压患者随机分为试验组23例和对照组21例。试验组给予比索洛尔2.5~5 mg/氢氯噻嗪6.25 mg复合剂,每天1次,口服;对照组给予缬沙坦80~160 mg,每天1次,口服,连续服药16周。每4周对血压的降低参数进行评估。结果治疗16周后,试验组和对照组的收缩压降低值分别为(-22.0±2.4)和(-19.5±3.0)mmHg,舒张压降低值分别为(-11.3±1.5)和(-10.3±2.1)mmHg,差异均无统计学意义(均P>0.05)。对照组和试验组心率降低值分别为(2.6±1.8)和(-8.4±1.6)beats·min^-1,差异有统计学意义(P<0.05)。治疗后,试验组的血浆尿素氮和谷丙转氨酶分别增高了0.7 mmol·L^-1和8.7 U·L^-1,而白蛋白和高密度脂蛋白胆固醇分别下降了1.5 g·L-1和0.1 mmol·L^-1。试验组与对照组均未出现严重药物不良反应,仅出现头痛、头晕、过敏等轻微药物不良反应,显示耐受性良好。结论低剂量组合的比索洛尔和氢氯噻嗪对于中国原发性高血压患者有良好的疗效及耐受性。Objective To compare the efficacy and tolerability of a combination of bisoprolol/HCTZ and valsartan in patients with essential hypertension.Methods Forty-four patients with essential hypertension were randomly divided into treatment group(23 patients)and control group(21 patients).Treatment group was given bisoprolol 2.5-5 mg,and hydrochlorothiazide 6.25 mg,control group was given valsartan 80 to 160 mg,once daily for 16 weeks.Reduction in blood pressure and changes of metabolic parameters were evaluated every 4 weeks.Results After 16 weeks treatment,the reduction of systolic blood pressure in treatment group and control group were(-22.0±2.4),(-19.5±3.0)mmHg,the reduction of diastolic blood pressure were(-11.3±1.5),(-10.3±2.1)mmHg,with no significant difference(P>0.05).The reduction of heart beats in treatment group and control group were(2.6±1.8),(-8.4±1.6)beats·min^-1,with significant difference(P<0.05).There was an increase in plasma levels of urea nitrogen(0.7 mmol·L^-1)and glutamic-pyruvic transaminase(8.7 U·L^-1),but a decrease in albumin(-1.5 g·L^-1)and high density cholesterol(-0.1 mmol·L^-1)in treatment group.There were no serious adverse drug reactions in treatment group and control group,only headache,dizziness,and allergies,indicating good tolerance.Conclusion The low-dose combination of bisoprolol and hydrochlorothiazide had an effective and tolerable antihypertensive profile in Chinese patients with essential hypertension.

关 键 词：比索洛尔 氢氯噻嗪 缬沙坦 高血压 

分 类 号：R972.[医药卫生—药品]