复合维生素对妊娠期妇女子痫前期发病率及妊娠结局的影响  

Effects of multivitamins on the incidence of preeclampsia and pregnancy outcome in pregnant women

作　　者：殷平珍[1] 李新[1] 李惠琴[1] 张爱英[1] YIN Ping-zhen;LI Xin;LI Hui-qin;ZHANG Ai-ying(Department of Obstetrics and Gynecology of Huaibei People’s Hospital,Huaibei 235000,China)

机构地区：[1]淮北市人民医院妇产科,安徽淮北235000

出　　处：《中国临床药理学杂志》2020年第14期1992-1994,共3页The Chinese Journal of Clinical Pharmacology

基　　金：2016年国家卫生计生委医药卫生科技发展研究中心基金资助项目(W2016CWAH06)。

摘　　要：目的观察复合维生素对妊娠期妇女子痫前期发病率、血清纤维蛋白原(FIB)水平及妊娠结局的影响。方法将本院孕检的140例妊娠期子痫前期高危孕妇随机分为试验组70例和对照组70例。对照组仅给予常规妊娠保健,试验组患者在对照组基础上给予复合维生素,每次1片,每天1次,睡前服用,持续服用至分娩。观察2组孕妇妊娠期间子痫前期发病率及治疗前后收缩压(SBP)、舒张压(DBP)、血清FIB水平及活化部分凝血酶时间(APTT)的变化,并对治疗后不良妊娠结局发生情况进行统计。结果妊娠期间试验组和对照组子痫前期发病率分别为11.43%(8例/70例)和28.57%(20例/70例),差异有统计学意义(P<0.05)。治疗后,试验组和对照组SBP水平分别为(115.77±9.98),(126.14±10.87)mmHg,DBP水平分别为(80.12±7.01),(88.03±7.46)mmHg,血清FIB水平分别为(2.58±0.40),(2.91±0.44)g·L^-1,APTT分别为(30.86±3.12),(29.34±3.24)s,差异均有统计学意义(均P<0.05)。治疗后,试验组和对照组不良妊娠结局发生率分别为12.86%(9例/70例)和34.29%(24例/70例),差异有统计学意义(P<0.05)。结论孕妇妊娠期间服用复合维生素可有效降低子痫前期和不良妊娠结局的发生率,尽快调整患者血压水平,改善FIB和APTT。Objective To explore the effects of multivitamins on the incidence of preeclampsia,the level of serum fibrinogen(FIB)and the outcome of pregnancy in pregnant women.Methods A total of 140 pregnant women with high risk of preeclampsia during pregnancy in our hospital were randomly divided into treatment group(70 cases)and control group(70 cases).Control group was only given routine pregnancy care,while treatment group were given multivitamin treatment on the basis of control group,given before sleep,qd,once a tablet per time,and continued to take it until delivery.The incidence of preeclampsia during pregnancy,the changes of systolic blood pressure(SBP),diastolic blood pressure(DBP),levels of serum FIB and activated partial thromboplastin time(APTT)before and after treatment were measured,and the incidence of adverse pregnancy outcome after treatment was statistically analyzed in two groups.Results The incidence rates of preeclampsia in treatment gorup and control group during pregnancy were 11.43%(8 cases/70 cases)and 28.57%(20 cases/70 cases),with significant difference(P<0.05).After treatment,the SBP in treatment gorup and control group were(115.77±9.98),(126.14±10.87)mmHg,DBP were(80.12±7.01),(88.03±7.46)mmHg,FIB were(2.58±0.40),(2.91±0.44)g·L^-1,APTT were(30.86±3.12),(29.34±3.24)s,all with significant difference(all P<0.05).After treatment,the incidence of adverse pregnancy outcomes in treatment gorup and control group were 12.86%(9 cases/70 cases)and 34.29%(24 cases/70 cases),with statistical significance(P<0.05).Conclusion Taking multivitamins during pregnancy can effectively reduce the incidence of preeclampsia and adverse pregnancy outcome of pregnant women,and can adjust the blood pressure level of patients as soon as possible,improve FIB,APTT.

关 键 词：复合维生素 子痫前期 发病率 纤维蛋白原 妊娠结局 

分 类 号：R97[医药卫生—药品]