cTnT、NT-proBNP对髋部骨折术后不良心血管事件的预测价值  

Predictive value of cTnT and NT-proBNP in adverse cardiovascular events after hip fracture surgery

作　　者：廖世亮 兰秀夫[1] 魏炳南[1] 余定华[1] 李科 田碧洪 LIAO Shiliang;LAN Xiufu;WEI Bingnan;YU Dinghua;LI Ke;TIAN Bihong(First Department of Orthopedics,Jiangbei Hospital of Traditional Chinese Medicine,Chongqing 400020,China)

机构地区：[1]重庆市江北区中医院骨伤一科,重庆400020

出　　处：《检验医学与临床》2020年第16期2289-2291,共3页Laboratory Medicine and Clinic

基　　金：重庆市卫生和计划生育委员会医学科研项目(2016MSXM133)。

摘　　要：目的探讨心肌肌钙蛋白T(cTnT)与氨基末端B型脑钠肽前体(NT-proBNP)对髋部骨折患者术后发生不良心血管事件的预测价值。方法选取2013年3月至2019年3月来该院治疗髋部骨折的531例患者为研究对象,其中发生不良心血管事件的57例患者作为观察组,未发生不良心血管事件的474例患者作为对照组,两组患者术后24h内cTnT与NT-proBNP水平进行检测,并分析其对患者术后发生不良心血管事件的影响。结果观察组术后24h内cTnT、NT-proBNP水平显著高于对照组,差异有统计学意义(P<0.05)。高浓度组术后发生不良心血管事件发病率显著高于低浓度组,差异有统计学意义(χ~2=12.76,P=0.00)。经Cox回归分析发现,高浓度组术后发生不良心血管事件的可能性是低浓度组的2.98倍(95%CI:1.59~5.62)。结论髋部骨折患者术后24h内cTnT、NT-proBNP水平对于其术后发生不良心血管事件具有重要的预测价值。Objective To investigate the predictive value of cardiac troponin T(cTnT)and N-terminal Btype brain natriuretic peptide precursor(NT-proBNP)for adverse cardiovascular events in patients with hip fracture after surgery.Methods Selected from March 2013 to March 2019 to the hospital treatment of 531 patients of hip fracture as the research object,which occurred adverse cardiovascular events of 57 patients as observation group,no adverse cardiovascular events in 474 patients as control group,two groups of patients within 24 hafter cTnT and NT-proBNP level detection,and analyzed its influence on patients with postoperative adverse cardiovascular events.Results The levels of cTnT and NT-proBNP in the observation group were significantly higher than those in the control group within 24 hafter operation,the difference was statistically significant(P<0.05).The incidence of adverse cardiovascular events in the high concentration group was significantly higher than that in the low concentration group (χ~2=12.76,P =0.00).Cox regression analysis showed that the probability of adverse cardiovascular events was 2.98 times higher in the high concentration group than in the low concentration group(95%CI:1.59-5.62).Conclusion The levels of cTnT and NTproBNP in patients with hip fracture within 24 hafter surgery have an important predictive value for the occurrence of adverse cardiovascular events after surgery.

关 键 词：心肌肌钙蛋白T 氨基末端B型脑钠肽前体 髋部骨折 

分 类 号：R687.3[医药卫生—骨科学]