维生素K1注射液对使用头孢哌酮舒巴坦ICU细菌性感染患者凝血功能的影响  

Effects of vitamin K1 injection on coagulation function in bacterial infected patients with cefoperazone sulbactam in ICU

作　　者：凌云 谭美春 LING Yun;TAN Meichun(Department of Emergency,Shanghai Baoshan District Combine Traditional Chinese and Western Medicine Hospital,Shanghai 201999,China)

机构地区：[1]上海市宝山区中西医结合医院急诊科,上海201999

出　　处：《检验医学与临床》2020年第16期2347-2349,共3页Laboratory Medicine and Clinic

摘　　要：目的探讨维生素K1注射液对重症监护室细菌性感染患者使用头孢哌酮舒巴坦凝血功能的影响。方法选取2017年7月至2018年12月该院急诊科收入重症监护室住院的细菌性感染患者75例作为研究对象,根据治疗时维生素K1注射液使用情况分为预防使用维生素K1注射液组(A组)、延迟使用维生素K1注射液组(B组)和不使用维生素K1注射液组(C组),3组均使用头孢哌酮舒巴坦抗感染治疗。观察比较各组凝血酶原时间(PT)、国际标准化比值(INR)、血小板计数(PLT)变化及有无新发出血,了解凝血功能紊乱情况。结果 A、B组患者治疗第7天、第12天出现凝血功能紊乱的比率低于C组,差异有统计学意义(P<0.05)。各组均出现新发出血,主要表现为血尿(A组1例)、皮肤新发瘀斑(B组1例、C组2例)及牙龈出血(C组1例)。均未见危及生命的出血及严重过敏反应。结论重症监护室使用头孢哌酮舒巴坦抗感染的患者补充维生素K1注射液可降低凝血功能紊乱的发生率。Objective To investigate the effect of vitamin K1 injection on coagulation function in bacterial infected patients with cefoperazone sulbactam in intensive care unit.Methods From July 2017 to December2018,75 bacterial infected patients admitted to the ICU from the emergency department of a hospital were selected as study subjects.According to the use of vitamin K1 injection during treatment,the patients were divided into three groups:preventive vitamin K1 injection group(group A),delayed vitamin K1 injection group(group B)and no vitamin K1 injection group(group C).Cefoperazone sulbactam were all given anti-infection treatment.The changes of prothrombin time(PT),international standard ratio(INR),platelet count(PLT)and newly emitted blood were observed and compared in each group to understand the disorder of coagulation function.Results The rate of coagulation dysfunction in group A and B was lower than that in group C on day7 and 12 after treatment,the difference was statistically significant(P<0.05).Newly emitted blood appeared in all groups,mainly manifested as hematuria(1 case in group A),new skin ecchymosis(1 case in group B,2 cases in group C)and gingival bleeding(1 case in group C).No life-threatening bleeding or severe allergic reactions were observed.Conclusion Vitamin K1 injection can reduce the incidence of coagulation disorders in patients with cefoperazone sulbactam anti-infection in intensive care unit.

关 键 词：维生素K1注射液 头孢哌酮舒巴坦 凝血功能 

分 类 号：R978.1[医药卫生—药品]