分泌型卷曲相关蛋白5评价心肌损伤的研究  

Evaluation of Myocardial Injury by Secretory Frizzled Protein 5

作　　者：何海涛[1] 丁福祥[1] HE Haitao;DING Fuxiang(Affiliated Hospital of Beihua University,Jilin 132011,China)

机构地区：[1]北华大学附属医院,吉林吉林132011

出　　处：《北华大学学报（自然科学版）》2020年第4期481-483,共3页Journal of Beihua University（Natural Science）

基　　金：吉林省教育厅科学技术研究项目(JJKH20170049KJ,JJKH20170053KJ);吉林市科技局卫生指导性计划项目(20200404095).

摘　　要：目的分析血清分泌型卷曲相关蛋白5(sFRP5)与心肌损伤实验室指标的相关性,探讨其对心肌损伤的临床评价.方法随机选取急性心肌梗死(AMI)患者及同时期健康体检者各60例,分为实验组和对照组.对比两组血清sFRP5及CK-MB、cTnI的差异;对比分析sFRP5水平与病情的关系,并对AMI组患者血清sFRP5与CK-MB、cTnI的相关性进行分析.结果AMI组患者血清sFRP5水平显著低于对照组,差异具有统计学意义(P<0.05);AMI组血清sFRP5与血清CK-MB、cTnI呈负相关;sFRP5在轻度AMI患者中的含量高于中度AMI,中度AMI高于重度AMI,差异具有统计学意义(P<0.05).结论心肌损伤患者血清sFRP5水平较对照组低,与心肌损伤实验室指标(CK-MB、cTnI)呈负相关,提示sFRP5可能是心肌损伤患者的保护因素,可作为AMI诊断及心肌损伤病情评估的临床参考指标.Objective To analyze the correlation between serum secreted frizzled protein 5(sFRP5)and laboratory markers of myocardial injury,and to explore its clinical evaluation of myocardial injury.Method Sixty patients with acute myocardial infarction(AMI)and concurrent physical examination were randomly selected from the experimental group and the control group.The differences of serum sFRP5,CK-MB and cTnI were compared between the two groups.The relationship between sFRP5 level and disease status was compared.The correlation between serum sFRP5,CK-MB and cTnI was analyzed.Results The serum sFRP5 level in patients with AMI was significantly lower than that in the control group(P<0.05).The difference was statistically significant.The serum sFRP5 in AMI group was negatively correlated with serum CK-MB and cTnI.The content of sFRP5 in mild AMI was higher than that of the moderate AMI.The moderate AMI was higher than the heavy AMI.The difference was statistically significant(P<0.05).Conclusion Serum sFRP5 levels in patients with myocardial injury were lower than those in the control group,and negatively correlated with myocardial injury laboratory indicators(CK-MB,cTnI),suggesting that sFRP5 may be a protective factor for patients with myocardial injury,and can be used as reference indicator in diagnosis of AMI and assessment of myocardial injur.

关 键 词：分泌型卷曲蛋白5 心肌损伤 评价作用 

分 类 号：R541[医药卫生—心血管疾病]