甘草酸二铵联合恩替卡韦对慢性乙型肝炎并肝硬化患者肝功能及肝纤维化的影响  

Influences of diammonium glycyrrhizinate combined with entecavir on liver function and liver fibrosis in patients with chronic hepatitis B and cirrhosis

作　　者：彭攀[1] PENG Pan(Center for Disease Control and Prevention of Puyang City,Puyang 457000,China)

机构地区：[1]濮阳市疾病预防控制中心,河南濮阳457000

出　　处：《临床医学研究与实践》2020年第23期57-59,共3页Clinical Research and Practice

摘　　要：目的观察甘草酸二铵联合恩替卡韦对慢性乙型肝炎并肝硬化患者肝功能及肝纤维化的影响。方法选择我中心2017年1月至2019年6月收治的200例慢性乙型肝炎并肝硬化患者,按照随机数表法分为对照组(100例,恩替卡韦)与观察组(100例,甘草酸二铵联合恩替卡韦)。比较两组的临床疗效、治疗前、后的肝功能、肝纤维化及血清炎症因子指标水平。结果观察组的治疗总有效率高于对照组(P<0.05)。治疗后,两组的GGT、AST、TBIL、HA、LN、CⅣ、hs-CRP、IL-6、MDA水平均降低,且观察组低于对照组(P<0.05)。结论甘草酸二铵联合恩替卡韦治疗慢性乙型肝炎并肝硬化患者,可有效减少肝损伤,抑制肝纤维化进程,降低炎症因子水平,整体效果较优。Objective To observe the influences of diammonium glycyrrhizinate combined with entecavir on liver function and liver fibrosis in patients with chronic hepatitis B and cirrhosis.Methods A total of 200 patients with chronic hepatitis B and cirrhosis admitted in our center from January 2017 to June 2019 were selected and divided into control group(100 cases,entecavir)and observation group(100 cases,diammonium glycyrrhizinate combined with entecavir)according to the random number table method.The clinical efficacy,liver function,liver fibrosis and serum inflammatory factors indexes levels before and after treatment were compared between the two groups.Results The total effective rate of treatment of the observation group was higher than that of the control group(P<0.05).After treatment,the levels of GGT,AST,TBIL,HA,LN,CⅣ,hs-CRP,IL-6 and MDA in both groups decreased,and those in the observation group were lower than the control group(P<0.05).Conclusion Diammonium glycyrrhizinate combined with entecavir in the treatment of patients with chronic hepatitis B and cirrhosis can effectively reduce liver damage,inhibit the progression of liver fibrosis,reduce the level of inflammatory factors,the overall effect is better.

关 键 词：甘草酸二铵 恩替卡韦 慢性乙型肝炎 肝硬化 

分 类 号：R512.62[医药卫生—内科学] R575.2[医药卫生—临床医学]