NO2对高血压患者血压和脉压的短期影响  

The short-term effects of NO2 on blood pressure and pulse pressure in patients with hypertension.

作　　者：石琴 郑山[1] 朱文芝 王敏珍[1] 缪茜 罗妍 聂永红 翁俊 李海燕[2] 白亚娜[1] SHI Qin;ZHENG Shan;ZHU Wen-zhi;WANG Min-zhen;MIAO Qian;LUO Yan;NIE Yong-hong;WENG Jun;LI Hai-yan;BAI Ya-na(Institute of Epidemiology and Statistics,School of Public Health,Lanzhou University,Lanzhou 730000,China;Workers'Hospital of Jinchuan Group Co.Ltd,Jinchang 737100,China)

机构地区：[1]兰州大学公共卫生学院流行病与卫生统计学研究所,甘肃兰州730000 [2]金川集团股份有限公司职工医院,甘肃金昌737100

出　　处：《中国环境科学》2020年第8期3627-3635,共9页China Environmental Science

基　　金：国家自然科学基金资助项目(41505095,41705122);兰州大学中央高校基本科研业务费专项资金资助项目(lzujbky-2018-69,lzujbky-2018-66)。

摘　　要：为了探讨气态污染物NO2对高血压患者血压水平和脉压的短期影响,本文基于前瞻性队列研究,收集甘肃省金昌市2011年1月1日~2015年11月30日逐日NO2监测数据及同期气象观测数据,运用混合效应模型,在控制随机效应及其他混杂因素的基础上,分析NO2与高血压患者血压水平和脉压的关联性.结果表明:(1)NO2在滞后1d(lag1)时平均浓度每升高1个IQR,收缩压升高0.457mmHg(0.131~0.784),滞后7d(lag7)和4d(lag4)时,NO2的平均浓度每升高1个IQR,舒张压上升0.276mmHg(0.025~0.527),脉压上升0.402mmHg(0.047~0.758),且结果均具有统计学意义.(2)性别、年龄、BMI、吸烟、饮酒、季节在NO2对高血压患者血压水平和脉压的效应中可能具有修饰作用.多污染物模型及调整沙尘影响后,NO2对高血压患者血压及脉压的影响保持一致.In order to explore the short-term effects of gaseous pollutants(NO2)on blood pressure(BP)and pulse pressure(PP)in patients with hypertension,the NO2 monitoring data and meteorological observation data were collected from January 1,2011 to November 30,2015 in Jinchang,Gansu Province.After controlling the random effect and other confounding factors,a mixed-effect model was used to analyze the association between NO2 and BP and PP in hypertensive patients based on a prospective cohort study.The results showed that:(1)An interquartile range(IQR)increase in NO2 at lag 1day was associated with a 0.457mmHg(95%CI:0.131~0.784)increase in systolic blood pressure(SBP);with each IQR increase of NO2,diastolic blood pressure(DBP)at lag 7 day and pulse pressure(PP)at lag 4 day increased 0.276mmHg(95%CI:0.025~0.527)and 0.402mmHg(95%CI:0.047~0.758),respectively.All the results was statistically significant.(2)Gender,age,BMI,smoking,drinking,and season may modify the effects of NO2 on BP and PP among hypertensive patients.The effects of NO2 on BP and PP remained consistent with the results in the multi-pollutant model or after adjusting dust weather.

关 键 词：NO2 高血压患者 混合效应模型 金昌队列 

分 类 号：X503.1[环境科学与工程—环境工程]