丙戊酸镁联合拉莫三嗪治疗难治性癫痫的效果及对血清IL-1β及IL-6水平的影响  

The efficacy of magnesium valproate combined with lamotrigine in the treatment of intractable epilepsy and its effect on the levels of serum IL-1β and IL-6

作　　者：王娜[1] 曹青青 杨青松[1] WANG Na;CAO Qingqing;YANG Qingsong(Department of Neurology,the First Peoples Hospital of Shangqiu City,Shangqiu(476000),Henann China)

机构地区：[1]商丘市第一人民医院神经内科,河南商丘476000,[2]吉林省人民医院神经内科

出　　处：《癫痫与神经电生理学杂志》2020年第4期220-222,共3页Journal of Epileptology and Electroneurophysiology(China)

摘　　要：目的:探讨丙戊酸镁联合拉莫三嗪治疗难治性癫痫的临床效果.以及对血清白介素-6(IL-6)、白介素-1β(1L-1β)的影响。方法:回顾性分析商丘市第一人民医院2019年1~6月期间接受丙戊酸镁联合拉莫三嗪治疗难治性癫痫的患者30例(观察组),另选取2018年5~12月期间收治的接受丙戊酸镁治疗的难治性癫痫患者30例(对照组).对比其临床疗效以及对血清前列腺素-E2(PGE2)JIL-1β和血清1L-6水平的影响。结果:治疗前两组血清炎症因子指标比较差异无统计学意义(P>0.05),治疗后观察组PGE2.L-6.IL-1β低于对照组(P<0,05);治疗前两组的阳性与阴性症状量表(PANSS)评分比较差异无统计学意义(P>0.05),治疗后,观察组PANSS评分低于对照组(P<0.05)。结论:将丙戊酸镁与拉莫三嗪联合应用对难治性癫痫炎症因子有明显抑制作用。Objective:To investigate the elinical fficacy,of magnesium valproate combined with lamotrigine in the treatment of intractable epilepsy and the ffect on the levels of serum IL.-6 and IL.-1β.Methods:From January 2019 to June 2019,30 patients with refractory epilepsy(as the observation group)were treated with magnesium valproate and lamotrigine in our hospital.Other 30 patients with refractory epilepsy(as the control group)merely treated with magnesium valproate from May 2018 to December 2018 were selected.The elinical efficacy,the levels of serum PGE2,IL-1βand serum IL-6 of the subjects were compared.Results:There was no significant difference in serum inflammatory factors and PANSS scores between the two groups before treatment(P>0.05)。After treatment.PGE2,IL-6 and IL-1βand PANSS scores in the observation group were lower than those in the control group(P<0.05).Conclusion:The application of magnesium valproate combined with lamotrigine can obviously inhibit the inflammatory factors of refractory epilepsy.

关 键 词：丙戊酸镁 拉莫三嗪 难治性癫痫 

分 类 号：R9716[医药卫生—药品] R742.1[医药卫生—药学]