炒与炒后碾去刺2种炮制法对苍耳子成分及药效的影响  

The Effect of Two Processing Methods of Frying and Grinding and Stabbing after Frying on the Composition and Efficacy of Xanthium Fruit

作　　者：陈亚芬[1] 黄群[1] 张周英[1] CHEN Yafen;HUANG Qun;ZHANG Zhouying(Department of Pharmacy,Maoming people's Hospital,Maoming 525000,China)

机构地区：[1]广东省茂名市人民医院药剂科,广东茂名525000

出　　处：《中国民族民间医药》2020年第15期21-24,共4页Chinese Journal of Ethnomedicine and Ethnopharmacy

摘　　要：目的:分析炒与炒后碾去刺2种炮制法对苍耳子成分及药效的影响。方法:通过水浸出物含量、脂肪油含量及其物理常数测定、薄层色谱分析、镇痛与毒性实验综合分析不同炮制法对苍耳子的影响。结果:苍耳子炒品与炒后碾去刺品的水浸出物含量、对小鼠的镇痛率明显高于生品(P<0.05),其中炒后碾去刺品的水浸出物含量、镇痛率最高。苍耳子炒品与炒后碾去刺品的脂肪油含量、对小鼠的致死率明显低于生品(P<0.05),炒品与炒后碾去刺品的脂肪油含量及对小鼠的致死率相比无明显差异(P>0.05)。苍耳子炮制后脂肪油物理常数及化学成分无明显变化。结论:炒后碾去刺炮制法更适用于苍耳子入药,在不明显改变其脂肪油物理常数及化学成分的情况下,可提升苍耳子镇痛效果,且毒性较小。Objective To analyze the effect of two processing methods of frying and grinding and stabbing after frying on the composition and efficacy of Xanthium fruit.Methods The effects of different processing methods on Xanthium fruit were analyzed by water extract content,fat oil content and its physical constants,TLC analysis,analgesic and toxicity experiments.Results The content of water extract and the analgesic rate to mice of stir fried and milled Xanthium fruit were significantly higher than those of raw Xanthium fruit(P<0.05),among which the content of water extract and the analgesic rate of milled Xanthium fruit were the highest.The content of fat oil and the lethal rate to mice of stir fried and milled products of Xanthium fruit were significantly lower than those of raw Xanthium fruit(P<0.05),and there was no significant difference in the content of fat oil and the lethal rate to mice between fried and milled Xanthium fruit(P>0.05).There was no significant change in physical constants and chemical components of fat oil after processing Xanthium fruit.Conclusion The method of grinding and stabbing after frying is more suitable for Xanthium fruit as medicine.It can improve the analgesic effect of Xanthium fruit without changing its physical constant and chemical composition of fat oil,and has less toxicity.

关 键 词：苍耳子 炮制 炒后碾去刺 成分 药效 

分 类 号：R283[医药卫生—中药学]