金属离子对肿瘤抑制蛋白p53影响的分子模拟  

The Molecular Simulation for the Influence of Metal Ions on Tumor Suppressor p53

作　　者：王卫京[1] 詹世平[1] 丁仕强[1] WANG Wei-jing;ZHAN Shi-ping;DING Shi-qiang(College of Environmental and Chemical Engineering,Dalian University,Dalian 116622,China)

机构地区：[1]大连大学环境与化学工程学院,辽宁大连116622

出　　处：《大连大学学报》2020年第3期33-35,共3页Journal of Dalian University

摘　　要：p53蛋白是一种肿瘤抑制蛋白,在人体内有重要的功能。本文通过分子模拟研究了金属离子Na^+,K^+,Ca^(2+),Mg^(2+),Zn^(2+)对p53蛋白的影响。模拟结果显示,Mg^(2+)离子导致p53蛋白RMSD值较大,说明Mg^(2+)引起蛋白质构象变化较大。Mg^(2+)影响p53蛋白核心区域与DNA结合能力,最终会影响p53蛋白功能。p53 protein is a tumor suppressor,and has important function in human body.The influence of metal ions Na+,K+,Ca2+,Mg2+,and Zn2+on p53 is investigated in this study by molecular simulation.The results of simulation reveal a larger value of RMSD for p53 protein that is caused by Mg2+,and a big change of protein conformation is caused by Mg2+also.The Mg2+affects the DNA-binding activity of p53 core domain and it affects the function of p53 finally.

关 键 词：P53 金属离子 分子模拟 

分 类 号：TQ015.9[化学工程]