基于靛红MBH碳酸酯参与不对称环化反应研究进展  

Research Progress on Asymmetric Cyclization Reaction Based on the Involvement of Indigored MBH Carbonate Ester

作　　者：刘林林[1] LIU Lin-lin(China Tianchen Engineering Corporation Ltd.,Tianjin 300400,China)

机构地区：[1]中国天辰工程有限公司,天津300400

出　　处：《广州化工》2020年第16期15-17,共3页GuangZhou Chemical Industry

摘　　要：MBH碳酸酯是一类活性较高、反应类型较为丰富的化合物,在叔膦或者叔胺的催化下,可以发生多种类型的环化反应,为有机杂环化合物的合成提供了更加便捷的方法。众所周知,吲哚片段常常存在于在天然产物或者具有生物活性的分子中,因此,将吲哚片段和MBH碳酸酯结合起来,将是一类非常有意义的分子,因此,基于靛红的MBH碳酸酯,在药物化学中具有良好的应用前景,本文对基于MBH碳酸酯参与的不对称环化反应做一简单的总结。MBH carbonates are a kind of compounds with high activity and rich reaction modes.Under the catalysis of tertiary phosphine or tertiary amine,MBH carbonates can undergo various cyclization reactions,which provides a more convenient method for the synthesis of organic heterocyclic compounds.It is well known that indole often exists in natural products or bioactive molecules.Therefore,the combination of indoles and MBH carbonates will be a very meaningful class of molecules.Therefore,isatin based MBH carbonate has a good application prospect in pharmaceutical chemistry.In this review,the asymmetric cyclization reaction based on MBH carbonate was briefly summarized.

关 键 词：MBH碳酸酯 靛红 药物分子 

分 类 号：O621[理学—有机化学]