咳嗽变异性哮喘(CVA)患者支气管肺泡灌洗液中炎症因子IL-5、IL-13水平的研究  

Study on the levels of inflammatory factors of IL-5 and IL-13 in bronchoalveolar lavage fluid in the patients with cough variant asthma(CVA)

作　　者：张雷[1] ZHANG Lei(Department of Respiratory Medicine,Suqian Hospital of TCM in Jiangsu Province,Suqian223800,China)

机构地区：[1]江苏省宿迁市中医院呼吸科,江苏宿迁223800

出　　处：《中国现代医生》2020年第20期18-22,共5页China Modern Doctor

摘　　要：目的研究咳嗽变异性哮喘(CVA)患者支气管肺泡灌洗液中炎症因子的水平。方法选取2018年4月~2019年10月在我院诊治的CVA患者75例为观察组,选取同期在我院诊治的非CVA慢性咳嗽患者75例为对照组,收集两组患者的支气管肺泡灌洗液,检测灌洗液中炎症因子IL-5、IL-13水平。结果CVA组患者灌洗液中的炎症因子IL-5、IL-13水平[(189.30±100.60)pg/L、(160.52±83.70)pg/L]明显高于非CVA组[(65.80±25.60)pg/L、(40.63±23.50)pg/L],差异有统计学意义(P<0.05)。结论诊断不明的慢性咳嗽患者可以行支气管肺泡灌洗液中炎症因子IL-5、IL-13水平检测以协助诊断。Objective To study the level of inflammatory factors in bronchoalveolar lavage fluid in the patients with cough variant asthma(CVA).Methods A total of 75 patients with CVA who were diagnosed and treated in our outpatient clinic and inpatient ward in our hospital from April 2018 to October 2019 were randomly selected into the observation group.75 patients with non-CVA chronic cough who were diagnosed and treated in the outpatient clinic and inpatient ward in our hospital during the same period were included in the control group.The bronchoalveolar lavage fluid was collected from both groups of patients,and the levels of IL-5 and IL-13 inflammatory factors in lavage fluid were tested.Results The levels of inflammatory factors IL-5 and IL-13 in the lavage fluid in the CVA group[(189.30±100.60)pg/L、(160.52±83.70)pg/L]were significantly higher than those in the non-CVA group[(65.80±25.60)pg/L、(40.63±23.50)pg/L],and the differences were statistically significant(P<0.05).Conclusion Patients with unknown diagnosis of chronic cough can be given the detection of levels of inflammatory factors IL-5 and IL-13 in bronchoalveolar lavage fluid for assisted diagnosis.

关 键 词：咳嗽变异性哮喘(CVA) 支气管肺泡灌洗液 IL-5 IL-13 

分 类 号：R256.12[医药卫生—中医内科学]