盐酸替罗非班在ST段抬高型急性心肌梗死急诊PCI中的临床疗效  

Clinical analysis of tirofiban hydrochloride in emergency PCI for ST-segment elevation acute myocardial infarction

作　　者：陈锋[1] 陈园园[1] 张伟[1] CHEN Feng;CHEN Yuanyuan;ZHANG Wei(Department of Cardiovascular Diseases,Lishui People's Hospital in Zhejiang Province,Lishui323000,China)

机构地区：[1]浙江省丽水市人民医院心血管内科,浙江丽水323000

出　　处：《中国现代医生》2020年第20期40-44,共5页China Modern Doctor

基　　金：浙江省中医药科技计划项目(2016ZB144)。

摘　　要：目的评价分析盐酸替罗非班在ST段抬高型急性心肌梗死急诊PCI中的临床疗效。方法以2017年1~12月本院治疗的ST段抬高型急性心肌梗死患者106例为研究对象,按入院号分为对照组53例,研究组53例;对照组接受基础治疗,研究组接受盐酸替罗非班治疗。比较两组治疗有效率、左室射血分数、6 min步行距离、左心室收缩末期内径、左心室舒张末期内径、心肌酶水平、肌钙蛋白、超敏C反应蛋白、白细胞介素-6、肿瘤坏死因子-α以及不良反应率。结果研究组的治疗总有效率、左室射血分数以及6 min步行距离高于对照组;研究组左心室收缩末期内径及左心室舒张末期内径低于对照组,研究组心功能较好,差异有统计学意义(P<0.05)。研究组治疗前的心肌酶水平以及肌钙蛋白与对照组比较,差异无统计学意义(P>0.05);研究组治疗后的心肌酶水平以及肌钙蛋白均低于对照组,差异有统计学意义(P<0.05);研究组超敏C反应蛋白、白细胞介素-6及肿瘤坏死因子-α均低于对照组,差异有统计学意义(P<0.05);研究组严重心律失常、心源性休克死亡、梗死后心绞痛及大出血等心血管不良事件发生率低于对照组,差异有统计学意义(P<0.05)。结论在ST段抬高型急性心肌梗死急诊PCI中采用盐酸替罗非班治疗,可改善患者微循环及心肌缺血状态,提高治疗效果,值得临床推广。Objective To evaluate the clinical efficacy of tirofiban hydrochloride in emergency PCI for ST-segment elevation acute myocardial infarction.Methods A total of 106 patients with ST-segment elevation acute myocardial infarction treated in our hospital from January to December 2017 were enrolled in the study.The patients were divided into the conventional group(53 cases,basic treatment)and the study group(53 cases,tirofiban hydrochloride).And then the treatment efficiency,left ventricular ejection fraction,six-minute walking distance,left ventricular end systolic diameter,left ventricular end diastolic diameter,myocardial enzyme level,and troponin and C-reactive protein,interleukin-6 and tumor necrosis factor-α,and adverse reaction rate between the two groups were compared.Results The total effective rate of the conventional group was lower(P<0.05).The left ventricular ejection fraction and the six-minute walking distance of the study group were higher than those of the conventional group.The left ventricular end-systolic diameter and the left ventricular end-diastolic diameter were lower than those of the conventional group.The cardiac function of the group was better(P<0.05).There was no significant difference in myocardial enzyme level and troponin between the study group and the conventional group before treatment(P>0.05).The myocardial enzyme and troponin levels in the study group were lower than those in the conventional group,and the difference was significant(P<0.05).The high-sensitivity C-reactive protein,interleukin-6 and tumor necrosis factor-αin the study group were lower than those in the conventional group(P<0.05).The incidence of cardiovascular events such as severe arrhythmia,cardiogenic shock death,post-infarction angina,and major bleeding in the study group was lower than that in the conventional group(P<0.05).Conclusion In the emergency PCI of ST-segment elevation acute myocardial infarction,treatment with tirofiban hydrochloride can improve the microcirculation and myocardial ischemia status,i

关 键 词：盐酸替罗非班 ST段抬高型急性心肌梗死 急诊PCI 临床疗效 

分 类 号：R542.2[医药卫生—心血管疾病]