阿维菌素凝胶微球的制备及性能评价  

The Preparation and Performance Evaluation of Avermectin Gel Microspheres

作　　者：朱海云 高萌萌 张洪悦 杨晓静 张保华[2] ZHU Hai-yun;GAO Meng-meng;ZHANG Hong-yue(College of Energy and Chemical Engineering,Ningxia Vocational Technical College of Industry and Commerce,Yinchuan,Ningxia 750021;New Pesticide Innovation and Research Institute,Qingdao Agricultural University,Qingdao,Shandong 266109)

机构地区：[1]宁夏工商职业技术学院能源化工学院,宁夏银川750021 [2]青岛农业大学新农药创制研究所,山东青岛266109

出　　处：《安徽农业科学》2020年第16期146-150,共5页Journal of Anhui Agricultural Sciences

基　　金：宁夏自然科学基金项目(2018AAC03198);宁夏高校科学研究项目(NGY2018209)。

摘　　要：以海藻酸钠和氯化钙为成球材料,以壳聚糖和PVA为覆膜材料,制备负载阿维菌素的凝胶微球。以载药率、包封率和溶胀率为主要筛选指标,通过正交试验优化,确定了最优制备工艺条件,各组分质量分数:海藻酸钠1%、氯化钙4%、壳聚糖2%、PVA 2%、戊二醛1.5%。同时,测定了阿维菌素凝胶微球的溶胀率和缓释性能。结果表明,凝胶微球在pH 7时溶胀率最大,温度和pH对载药微球的缓释性能有一定影响。Alginate and calcium chloride were used as ball forming materials, chitosan and PVA as coating materials,gel microspheres loading avermectin were prepared. Taking the drug loading rate, encapsulation rate and swelling rate as the investigation indexs, the preparation conditions were determined by orthogonal experiment optimization,the mass fraction of each component was:sodium alginate 1%, calcium chloride 4%, chitosan 2%, polyvinyl alcohol(PVA) 2%, glutaraldehyde 1.5%. At the same time, the swelling and slow release properties of avermectin gel microspheres were measured. The results showed that the swelling rate of gel microspheres was the largest at pH 7, and temperature and pH had certain effects on the sustained release properties of avermectin gel microspheres.

关 键 词：阿维菌素 凝胶微球 优化 性能 

分 类 号：TQ460[化学工程—制药化工]