2-氨基-6-氯烟酸的合成工艺优化  

Optimization of Synthesis Process of 2-amino-6-chioronatenic Acidnic Acid

作　　者：代正义 路宇航 黄文婧 张梅 姜西 乐意[1,2] 周志旭 Dai Zhengyi;Lu Yuhang;Huang Wenjing;Zhang Mei;Jiang Xi;Le Yi;Zhou Zhixu(School of Pharmaceutical Sciences,Guizhou University,Guiyang 550025;Guizhou Engineering Laboratory for Synthetic Drugs,Guiyang 550025,China)

机构地区：[1]贵州大学药学院,贵州贵阳550025 [2]贵州省合成药物工程实验室,贵州贵阳550025

出　　处：《广东化工》2020年第15期8-8,共1页Guangdong Chemical Industry

基　　金：贵州大学大学生“SRT计划”项目,合同编号:贵大SRT字(2018)134号。

摘　　要：2-氨基-6-氯烟酸合成是m TOR抑制剂AZD8055、AZD2014等药物的重要中间体。本文以2,6-二氯烟酸为原料对2-氨基-6-氯烟酸的合成进行了研究。优化后的合成方法原料易得、后处理简便且产物纯度高,收率为90.2%,适合工业化生产。2-Amino-6-chloroniacin is an important organic intermediate of m TOR inhibitors AZD8055 and AZD2014. In this paper, the target compound was synthesized by one-pot reaction with 2,6-dichloronicotinic acid as the starting material. The route has the advantages of low cost and easy availability, convenient post-treatment and high yield, and is suitable for industrial production. The total yield was 90.2 %.

关 键 词：2 6-二氯烟酸 2-氨基-6-氯烟酸 合成 工艺优化 

分 类 号：TQ[化学工程]