三维分层脑组织的建立及DBS刺激电极下移仿真研究  

Establishment of Three-Dimensional Stratified Brain Tissue and Simulation of DBS Stimulating Electrode Descending

作　　者：王琦 陈义保[1] 柴永生[1] 李岩[1] 刘希宽 李林 刘宇航 WANG qi;CHEN Yi-bao;CHAI Yong-sheng;LI Yan;LIU Xi-kuan;LI lin;LIU Yu-hang(School of Mechanical and Automotive Engineering,Yantai University,Yantai 264005,China)

机构地区：[1]烟台大学机电汽车工程学院,山东烟台264005

出　　处：《烟台大学学报（自然科学与工程版）》2020年第3期333-340,共8页Journal of Yantai University(Natural Science and Engineering Edition)

基　　金：国家自然科学基金资助项目(51805463);山东省自然科学基金博士基金资助项目(ZR2018BEE022).

摘　　要：针对手术过程脑组织内部不可透视的问题,采用有限元的方法构建三维分层脑组织,并对刺激电极的移位进行了仿真研究.结果显示丘脑底核的漂移大致为电极下移数据的一半,减小摩擦系数可以降低靶点漂移,但效果并不明显,得出电极的移位会造成丘脑底核的下移.产生靶点位移的主要原因是由于刺激电极对丘脑底核下层脑组织的挤压作用造成的.建立的三维脑组织-电极仿真模型可以为脑深部刺激术中或术后调整电极提供理论指导,实现电极更精准的定位,满足临床需求.In view of the problem that the inside of the brain tissue can not be seen during surgery,in this paper the finite element method has been adopted to construct three-dimensional layered brain tissue,and the shifting of stimulating electrodes has been simulated.The results show that the drift of the subthalamic nuclei is about half of the data of electrode shifting down,friction coefficient reduction can lower the target drift,but it is not obviously effective,so it can be seen that the shift of the electrode will cause the downshift of the subthalamic nuclei.The main reason for target shifting is due to the squeezing action of stimulating electrodes on the lower brain tissue of subthalamic nuclei.The established three-dimensional brain tissue-electrode simulation model can provide theoretical guidance for adjusting the electrodes during or after deep brain stimulation,so as to achieve more accurate electrode positioning and meet the clinical needs.

关 键 词：分层脑组织模型 电极移位 靶点漂移 深部脑刺激 有限元 

分 类 号：TP399[自动化与计算机技术—计算机应用技术]